5-CYANO-2,3-DIHYDRO-1H-INDOLE
- Product Name
- 5-CYANO-2,3-DIHYDRO-1H-INDOLE
- CAS No.
- 15861-23-1
- Chemical Name
- 5-CYANO-2,3-DIHYDRO-1H-INDOLE
- Synonyms
- 5-Cyanoindoline;5-Indolinecarbonitrile;Indoline-5-carbonitrile ,97%;5-CYANO-2,3-DIHYDRO-1H-INDOLE;Indoline-5-carbonitrile - [K72445];2,3-dihydro-1H-indole-5-carbonitrile;1H-Indole-5-carbonitrile, 2,3-dihydro-;5-Cyanoindoline 5-CYANO-2,3-DIHYDRO-1H-INDOLE in stock Factory
- CBNumber
- CB1399079
- Molecular Formula
- C9H8N2
- Formula Weight
- 144.17
- MOL File
- 15861-23-1.mol
5-CYANO-2,3-DIHYDRO-1H-INDOLE Property
- Melting point:
- 93-94°C
- Boiling point:
- 304.4±31.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.77±0.20(Predicted)
- form
- Solid
- color
- Off-White
Safety
- Safety Statements
- 24/25
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C955825
- Product name
- 5-Cyano-2,3-dihydro-1H-indole
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- C955825
- Product name
- 5-Cyano-2,3-dihydro-1H-indole
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- FC52080
- Product name
- 5-Cyano-2,3-dihydro-1H-indole
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR953724
- Product name
- 5-Cyano-2,3-dihydro-1H-indole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC52080
- Product name
- 5-Cyano-2,3-dihydro-1H-indole
- Packaging
- 50mg
- Price
- $104.5
- Updated
- 2021/12/16
5-CYANO-2,3-DIHYDRO-1H-INDOLE Chemical Properties,Usage,Production
Chemical Properties
Light pink solid
Synthesis
15861-24-2
15861-23-1
General procedure for the synthesis of 5-indolinecarbonitrile from 5-cyanoindole: 5-cyanoindole (1 g, 7 mmol) was dissolved in 10 mL of trifluoroacetic acid (TFA) and the solution was cooled to 0 °C. Subsequently, triethylsilane (1.6 g, 14 mmol, 2 equiv) was added to the solution. The reaction mixture was kept stirred at 0 °C for 4 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed with 1 M hydrochloric acid (HCl) solution. The aqueous layers were combined, neutralized to pH 10 with 50% sodium hydroxide (NaOH) solution and then extracted three times with ethyl acetate. The organic extracts were combined, washed with saturated brine, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the target product 5-indolinecarbonitrile in 77% yield.
References
[1] Patent: US2004/220206, 2004, A1. Location in patent: Page 25-26
[2] Journal of Materials Chemistry A, 2015, vol. 3, # 34, p. 17704 - 17712
[3] Patent: CN105085504, 2018, B. Location in patent: Paragraph 0139; 0147-0150
[4] Patent: WO2014/188173, 2014, A1. Location in patent: Paragraph 00239; 00521
[5] Patent: US2004/220206, 2004, A1. Location in patent: Page 25
5-CYANO-2,3-DIHYDRO-1H-INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYANO-2,3-DIHYDRO-1H-INDOLE manufacturers
- Product
- 5-Cyanoindoline 5-CYANO-2,3-DIHYDRO-1H-INDOLE in stock Factory 15861-23-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- 5-CYANO-2,3-DIHYDRO-1H-INDOLE 15861-23-1
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24