ChemicalBook > CAS DataBase List > 5-CYANO-2,3-DIHYDRO-1H-INDOLE

5-CYANO-2,3-DIHYDRO-1H-INDOLE

Product Name: 5-CYANO-2,3-DIHYDRO-1H-INDOLE
CAS No.: 15861-23-1
Chemical Name: 5-CYANO-2,3-DIHYDRO-1H-INDOLE
Synonyms: 5-Cyanoindoline;5-Indolinecarbonitrile;Indoline-5-carbonitrile ,97%;5-CYANO-2,3-DIHYDRO-1H-INDOLE;Indoline-5-carbonitrile - [K72445];2,3-dihydro-1H-indole-5-carbonitrile;1H-Indole-5-carbonitrile, 2,3-dihydro-;5-Cyanoindoline 5-CYANO-2,3-DIHYDRO-1H-INDOLE in stock Factory
CBNumber: CB1399079
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 15861-23-1.mol

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5-CYANO-2,3-DIHYDRO-1H-INDOLE Property

Melting point:: 93-94°C
Boiling point:: 304.4±31.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.77±0.20(Predicted)
form: Solid
color: Off-White

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C955825
Product name: 5-Cyano-2,3-dihydro-1H-indole
Packaging: 250mg
Price: $90
Updated: 2021/12/16

TRC

Product number: C955825
Product name: 5-Cyano-2,3-dihydro-1H-indole
Packaging: 500mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC52080
Product name: 5-Cyano-2,3-dihydro-1H-indole
Packaging: 25mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR953724
Product name: 5-Cyano-2,3-dihydro-1H-indole
Purity: 98%
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC52080
Product name: 5-Cyano-2,3-dihydro-1H-indole
Packaging: 50mg
Price: $104.5
Updated: 2021/12/16

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5-CYANO-2,3-DIHYDRO-1H-INDOLE Chemical Properties,Usage,Production

Chemical Properties

Light pink solid

Synthesis

15861-24-2

15861-23-1

General procedure for the synthesis of 5-indolinecarbonitrile from 5-cyanoindole: 5-cyanoindole (1 g, 7 mmol) was dissolved in 10 mL of trifluoroacetic acid (TFA) and the solution was cooled to 0 °C. Subsequently, triethylsilane (1.6 g, 14 mmol, 2 equiv) was added to the solution. The reaction mixture was kept stirred at 0 °C for 4 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed with 1 M hydrochloric acid (HCl) solution. The aqueous layers were combined, neutralized to pH 10 with 50% sodium hydroxide (NaOH) solution and then extracted three times with ethyl acetate. The organic extracts were combined, washed with saturated brine, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the target product 5-indolinecarbonitrile in 77% yield.

References

[1] Patent: US2004/220206, 2004, A1. Location in patent: Page 25-26
[2] Journal of Materials Chemistry A, 2015, vol. 3, # 34, p. 17704 - 17712
[3] Patent: CN105085504, 2018, B. Location in patent: Paragraph 0139; 0147-0150
[4] Patent: WO2014/188173, 2014, A1. Location in patent: Paragraph 00239; 00521
[5] Patent: US2004/220206, 2004, A1. Location in patent: Page 25

5-CYANO-2,3-DIHYDRO-1H-INDOLE Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide Palladium (II) Acetate Acetonitrile Ethanol Acetyl chloride Sodium Triethylamine Indoline Sodium nitrite Sodium cyanide Tetrahydrofuran Benzene Hydrochloric acid Nitric acid Sodium hydroxide Sulfuric acid Carbon Sodium carbonate

Preparation Products

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View Lastest Price from 5-CYANO-2,3-DIHYDRO-1H-INDOLE manufacturers

Chemwill Asia Co.,Ltd.

Product: 5-Cyanoindoline 5-CYANO-2,3-DIHYDRO-1H-INDOLE in stock Factory 15861-23-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 5-CYANO-2,3-DIHYDRO-1H-INDOLE 15861-23-1
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

15861-23-1, 5-CYANO-2,3-DIHYDRO-1H-INDOLERelated Search:

Hydrochlorothiazide Potassium Phosphate Monobasic 5-Cyanoindole 5-CYANOOXINDOLE BUTTPARK 52\04-51 BUTTPARK 120\07-93 BUTTPARK 52\04-55 3-(methylthio)-2-oxoindoline-5-carbonitrile 5-CYANO-2,3-DIHYDRO-1H-INDOLE 5-CYANO-3,3-DIMETHOXYOXOINDOLE

5-CYANO-2,3-DIHYDRO-1H-INDOLE

Indoline-5-carbonitrile ,97%

2,3-dihydro-1H-indole-5-carbonitrile

5-Indolinecarbonitrile

5-Cyanoindoline

5-Cyanoindoline 5-CYANO-2,3-DIHYDRO-1H-INDOLE in stock Factory

1H-Indole-5-carbonitrile, 2,3-dihydro-

Indoline-5-carbonitrile - [K72445]

15861-23-1