ChemicalBook > CAS DataBase List > ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE

ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE

Product Name: ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE
CAS No.: 34632-69-4
Chemical Name: ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE
Synonyms: 4-Chloro-2-(ethoxycarbonyl)quinazoline;Ethyl 4-chloro-quinazolin-2-carboxylate;Ethyl 4-chloroquinazoline-2-carboxylate;ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE;2-Quinazolinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-2-Quinazolinecarboxylic acid ethyl ester (9CI ACI);2-Quinazolinecarboxylic acid, 4-chloro-, ethyl ester (9CI, ACI)
CBNumber: CB1405169
Molecular Formula: C11H9ClN2O2
Formula Weight: 236.65
MOL File: 34632-69-4.mol

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ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE Property

Melting point:: 100-101°C
Boiling point:: 391.3±34.0 °C(Predicted)
Density: 1.341±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -0.74±0.30(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C11H9ClN2O2/c1-2-16-11(15)10-13-8-6-4-3-5-7(8)9(12)14-10/h3-6H,2H2,1H3
InChIKey: ZMAJSODACDWUAS-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC=C2)=C(Cl)N=C1C(OCC)=O

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000658
Product name: Ethyl 4-chloroquinazoline-2-carboxylate
Packaging: 1 g
Price: $259
Updated: 2025/07/31

TRC

Product number: E901790
Product name: Ethyl4-Chloroquinazoline-2-carboxylate
Packaging: 1g
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 048110
Product name: Ethyl 4-chloro-2-quinazolinecarboxylate
Purity: >95%
Packaging: 1g
Price: $454
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-W6
Product name: Ethyl 4-chloroquinazoline-2-carboxylate
Packaging: 1g
Price: $360
Updated: 2021/12/16

Matrix Scientific

Product number: 048110
Product name: Ethyl 4-chloro-2-quinazolinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $362
Updated: 2021/12/16

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ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 4-Chloroquinazoline-2-carboxylate is a reactant used in the synthesis and evaluation of novel quinazoline-based anti-inflammatory agents acting as PDE4B inhibitors.

Synthesis

29113-33-5

34632-69-4

General procedure for the synthesis of ethyl 4-chloroquinazoline-2-carboxylate from ethyl 4-quinazolinone-2-carboxylate: To a suspension of ethyl 4-quinazolinone-2-carboxylate (1.2 g, 5.5 mmol) in chloroform (20 mL) was added sequentially N,N-dimethylformamide (6 drops) and thionyl chloride (4.8 mL, 66 mmol). The reaction mixture was heated to reflux for 4.5 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. Ice water was added to the residue and a white solid precipitated. The solid product was collected by filtration, washed with cold water and dried to afford ethyl 4-chloroquinazoline-2-carboxylate (1.26 g, 97% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.38 (dd, J = 0.74 Hz, 8.34 Hz, 1H), 8.31 (d, J = 8.48 Hz, 1H), 8.07 (m, 1H), 7.87 (m, 1H), 4.61 (q, J = 7.12 Hz, 2H), 1.50 (t, J = 7.14 Hz, 3H).IR spectra (diamond cell, cm-1 ) showed characteristic absorption peaks: νmax 1731.3, 1549.8, 1479.8, 1338.4, 1179.4, 913.0, 764.3, 693.9.Melting point is 86-88 °C.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 18, p. 5045 - 5048
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1701 - 1715
[3] Patent: WO2004/14844, 2004, A2. Location in patent: Page 187-188
[4] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 2, p. 102 - 116

ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE 34632-69-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

34632-69-4, ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATERelated Search:

4-CHLORO-QUINAZOLINE ethyl 4-chloroquinazoline-6-carboxylate ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE 4-chloro-2-methylquinazoline 5-CHLOROPYRIMIDINE-2-CARBALDEHYDE ETHYL 4-CHLORO-6-METHOXYQUINAZOLINE-2-CARBOXYLATE 4-chloropyrimidine-2-carboxylic acid ETHYL 4,6-DICHLOROQUINAZOLINE-2-CARBOXYLATE

4-Chloro-2-(ethoxycarbonyl)quinazoline

ETHYL 4-CHLORO-2-QUINAZOLINECARBOXYLATE

Ethyl 4-chloroquinazoline-2-carboxylate

2-Quinazolinecarboxylic acid, 4-chloro-, ethyl ester

2-Quinazolinecarboxylic acid, 4-chloro-, ethyl ester (9CI, ACI)

4-chloro-2-Quinazolinecarboxylic acid ethyl ester (9CI ACI)

Ethyl 4-chloro-quinazolin-2-carboxylate

34632-69-4

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