4-chloro-2-methylquinazoline
- Product Name
- 4-chloro-2-methylquinazoline
- CAS No.
- 6484-24-8
- Chemical Name
- 4-chloro-2-methylquinazoline
- Synonyms
- 4-chloro-2-methylquinazoline;Quinazoline, 4-chloro-2-Methyl-;4-Chloro-2-methylquinazoline?New
- CBNumber
- CB01078981
- Molecular Formula
- C9H7ClN2
- Formula Weight
- 178.62
- MOL File
- 6484-24-8.mol
4-chloro-2-methylquinazoline Property
- Melting point:
- 86-88 °C
- Boiling point:
- 211.2±23.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 1.28±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368293
- Product name
- 4-Chloro-2-methylquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC144201
- Product name
- 4-Chloro-2-methylquinazoline
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 073604
- Product name
- 4-Chloro-2-methylquinazoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- FC144201
- Product name
- 4-Chloro-2-methylquinazoline
- Packaging
- 2g
- Price
- $219
- Updated
- 2021/12/16
- Product number
- 073604
- Product name
- 4-Chloro-2-methylquinazoline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $235
- Updated
- 2021/12/16
4-chloro-2-methylquinazoline Chemical Properties,Usage,Production
Synthesis
1769-24-0
6484-24-8
The general procedure for the synthesis of 4-chloro-2-methylquinazoline from 4-hydroxy-2-methylquinazoline was as follows: first, starting from commercially purchased 2-methylquinazolin-4(3H)-one, the chlorination reaction was carried out at the 4-position using POCl3 according to the microwave-assisted procedure as previously reported [25], which ultimately afforded 4-chloro-2-methylquinazoline in 73% yield. Subsequently, the product was applied to the synthesis of the intermediate according to the general DMAP-catalyzed procedure described in κ 3.1.3 to give molecule 37 as a beige powder in 45% yield. The melting point of the product was 118 °C (isopropanol).1H NMR (200 MHz, CDCl3) δ = 8.33 (d, J = 8 Hz, 1H), 7.95-7.83 (m, 3H), 7.65-7.56 (m, 2H), 7.42-7.25 (m, 2H), 2.59 (s, 3H), 2.47 (s, 3H).13C NMR (50 MHz, CDCl3) δ=197.9,166.3,163.7,152.0,150.9,134.3,133.3,132.0,130.1,127.1,127.0,126.0,123.8,123.4,114.3,30.1,26.2. LC-MS (ESI+) tR 4.60 min, m/z [M+H]+ 279.19. molecular weight: 278.31 g/mol. calculated value of C17H14N2O2: C, 73.37; H, 5.07; N, 10.07. measured value: C, 73.82; H, 5.11; N, 9.93.
References
[1] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 6, p. 840 - 847
[3] MedChemComm, 2013, vol. 5, # 11, p. 1700 - 1707
[4] Tetrahedron, 2014, vol. 70, # 44, p. 8257 - 8266
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 34 - 44
4-chloro-2-methylquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-chloro-2-methylquinazoline manufacturers
- Product
- 4-chloro-2-methylquinazoline 6484-24-8
- Price
- US $500.00-400.00/KG
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-03