2-METHYL-M-PHENYLENE DIISOCYANATE Property

Melting point:

13°C

Boiling point:

129-133 °C18 mm Hg(lit.)

Density 

1.225 g/mL at 25 °C(lit.)

vapor pressure 

2.78Pa at 25℃

refractive index 

n20/D 1.571(lit.)

Flash point:

>230 °F

storage temp. 

−20°C

form 

Liquid

color 

Clear colorless to light yellow

Water Solubility 

It hydrolyzes in water.

Sensitive 

Moisture Sensitive

BRN 

2211546

Exposure limits

ACGIH: TWA 0.001 ppm; STEL 0.005 ppm (Skin)

Stability:

Stability Reacts violently with water. Reacts very rapidly with compounds containing an active hydrogen, such as amines, alcohols and acids. Polymerizes rapidly in the presence of base. Combustible. Incompatible with strong oxidizing agents.

LogP

3.74

CAS DataBase Reference

91-08-7(CAS DataBase Reference)

EPA Substance Registry System

Toluene-2,6-diisocyanate (91-08-7)

Safety

Hazard Codes 

T+

Risk Statements 

26-36/37/38-40-42/43-52/53

Safety Statements 

23-36/37-45-61

RIDADR 

UN 2078 6.1/PG 2

WGK Germany 

2

RTECS 

CZ6310000

F 

8-10-19-21

Autoignition Temperature

>1148 °F

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29291090

Hazardous Substances Data

91-08-7(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-METHYL-M-PHENYLENE DIISOCYANATE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

2-Methyl-m-phenylene Diisocyanate is used in method for preparing breathable sweat-absorbing EVA foam shoe material.

Uses

2,6-TDI may be used as a reference standard for the quantification of residual 2,6-TDI in foam samples using high performance liquid chromatography coupled to coordination-ionspray tandem mass spectrometry (HPLC-CIS-MS/MS).

Definition

ChEBI: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 257, 1995 DOI: 10.1021/jo00106a044

General Description

Liquid. Used in the manufacture of polyurethane foams, elastomers, and coatings; crosslinking agent for nylon 6.

Reactivity Profile

2-METHYL-M-PHENYLENE DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. [Handling Chemcials Safely 1980. p. 907]. Reaction with water to form Carbon Dioxide [Merck 11th ed. 1989].

Health Hazard

Classified as slightly toxic orally. Probable oral lethal dose in humans is 5 to 15 g/kg or between 1 pint and 1 quart for a 70 (l50 lb.) person. Particularly poisonous when breathed. This is among the most poisonous of isocyanates. Acute and chronic exposures to low concentrations may produce asthmatic attacks.

Fire Hazard

When heated to decomposition, 2-METHYL-M-PHENYLENE DIISOCYANATE emits toxic fumes of nitrogen oxides. Ventilation should be adequate. If polyurethane products are heated, protection against isocyanate release is necessary. Avoid decomposing heat.

Flammability and Explosibility

Non flammable

Safety Profile

Confirmed carcinogen. Poison by ingestion and inhalation. Human systemic effects by inhalation: olfactory, eye, and pulmonary changes. Flammable liquid. When heated to decomposition it emits toxic fumes of NOx. See also CYANATES.

Purification Methods

It is purified by fractional distillation in a vacuum. Store it under N2 in sealed dark ampoules as it is water and light sensitive. Like the preceding 2,4-isomer, it has a sharp pungent odour, is TOXIC and is IRRITATING TO THE EYES. [Beilstein 13 IV 259.]