11-KETO-BETA-BOSWELLIC ACID

Product Name: 11-KETO-BETA-BOSWELLIC ACID
CAS No.: 17019-92-0
Chemical Name: 11-KETO-BETA-BOSWELLIC ACID
Synonyms: Pharoxifene;Raloxifenum;11-Oxo-β-boswellic Acid;11-Oxo-β-boswellic acid;β-Boswellic acid,11-keto;11-keto-β-Boswellic Acid;β-Boswellic acid,11-keto;Boswellic Acid Impurity 2;11-KETO-BETA-BOSWELLIC ACID;Beta-boswellic acid,11-keto
CBNumber: CB1415526
Molecular Formula: C30H46O4
Formula Weight: 470.68
MOL File: 17019-92-0.mol

More

Less

11-KETO-BETA-BOSWELLIC ACID Property

Melting point:: 190～192℃
Boiling point:: 591.8±50.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: ≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
pka: 4.46±0.70(Predicted)
color: White
Water Solubility: insoluble in water
InChIKey: YIMHGPSYDOGBPI-IQQSWPBXSA-N
LogP: 7.100 (est)

More

Less

Safety

WGK Germany: 3
HS Code: 29189900

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89169
Product name: 11-Keto-β-boswellic acid
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $584
Updated: 2024/03/01

Sigma-Aldrich

Product number: 78535
Product name: 11-Keto-β-boswellic acid
Purity: analytical standard
Packaging: 5mg
Price: $561
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 5mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 10mg
Price: $684
Updated: 2024/03/01

More

Less

11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

Uses

A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.

Biological Activity

37.9 μm: blocks a2780 (cis-platin resistant ovarian cancer cells) [1].11-keto-β-boswellic acid, known as kba, is a naturally occurring pentacyclic triterpene isolated from the gum resin of the tree boswellia serrata. kba is non-redox, specific leukotriene synthesis inhibitors through the inhibition of 5-lipoxygenase (5-lox) which has anti-arthritic and anti-inflammatory activities. 5-lox catalyzes essential fatty acids substrates into leukotrienes and a variety of other biologically active products. kba is a novel activator of nuclear factor erythroid-2-related factor 2 (nrf2), which protects against cerebral ischemic injury.

in vitro

kba, concentration dependently, decreased the formation of leukotriene b4 and the synthesis of all 5-lox products from endogenous arachidonic acid in rat peritoneal neutrophils. in contrast, kba exerted no remarkable effects on the 12-lipoxygenase and cyclooxygenase activities. [2].

in vivo

adult male sprague–dawley rats were injected kab intraperitoneally at a dose of 25 mg/kg for 48 hours. kab remarkably decreased infarct volumes as well as apoptotic cells at 1 h, and then increased neurologic scores when applied 48 h. moreover, posttreatment with kba induced the decrease of malondialdehyde levels and the increase of protein nrf2 and heme oxygenase-1 expression in brain tissues, indicating that the nrf2/ho-1 pathway was involved in the neuroprotection of kba against oxidative stress-induced ischemic injury [3].

IC 50

35.8 μm: inhibits mcf-7 (human breast adenocarcinoma) [1].

References

[1]. csuk, r., barthel-niesen, a., barthel, a., schffer, r., & al-harrasi, a. 11-keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells. european journal of medicinal chemistry. 2015; 100: 98-105.
[2]. safayhi, h., mack, t. h. o. m. a. s., sabieraj, j. o. a. c. h. i. m., anazodo, m. i., subramanian, l. r., & ammon, h. p. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. journal of pharmacology and experimental therapeutics. 1992; 261(3):1143-1146.
[3]. ding, y., chen, m., wang, m., li, y., & wen, a. posttreatment with 11-keto-β-boswellic acid ameliorates cerebral ischemia–reperfusion injury: nrf2/ho-1 pathway as a potential mechanism. molecular neurobiology. 2014; 52(3): 1430-1439.

11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

11-KETO-BETA-BOSWELLIC ACID Suppliers

Canada 2 China 118 France 1 Germany 5 India 4 Norway 1 Switzerland 1 Ukraine 1 United Kingdom 5 United States 14 USA 1 Global 153

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-1865138 13341702378
Fax: QQ：190129269
Email: 190129269@qq.com
Country: China
ProdList: 1010
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3924
Advantage: 50

Shanghai Zhanshu Chemical Technology Co., Ltd

Tel: +86-21-58589556
Fax: +86-21-58589557
Country: China
ProdList: 413
Advantage: 55

More

Less

View Lastest Price from 11-KETO-BETA-BOSWELLIC ACID manufacturers

R&D Scientific Inc.

Product: 11-Keto-beta-boswellic acid 17019-92-0
Price: US $1400.00/mg
Min. Order: 1mg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-03-31

Career Henan Chemical Co

Product: 11-KETO-BETA-BOSWELLIC ACID 17019-92-0
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

17019-92-0, 11-KETO-BETA-BOSWELLIC ACIDRelated Search:

Corosolic acid Ursolic acid Ursodeoxycholic acid β-Elemonic Acid 3-ACETYL-BETA-BOSWELLIC ACID (3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID,3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID,ACETYL-11-KETO-BETA-BOSWELLIC ACID CIS-13-EICOSENOIC ACID 2-METHYL-6-OXO-HEPTANOIC ACID BETA-BOSWELLIC ACID ALPHA-BOSWELLIC ACID Erucic Acid BRASSIDIC ACID 11-KETO-BETA-BOSWELLIC ACID

11-KETO-BETA-BOSWELLIC ACID

(3α,4β)-3-Hydroxy-11-oxours-12-en-23-oic Acid

11-Oxo-β-boswellic Acid

3α-Hydroxy-11-oxours-12-en-24-oic Acid

3-Hydroxy-11-oxo-12-ursen-24-oic acid

KETO-B-BOSWELLIC ACID, 11-(SH)

Beta-boswellic acid,11-keto

β-Boswellic acid,11-keto

11-Keto-β-boswellic acid, 98%, from Boswellia carterii Birdw

Boswellic Acid Impurity 2

Urs-12-en-23-oic acid, 3-hydroxy-11-oxo-, (3α,4β)-

11-keto-β-Boswellic Acid

11-KETO-BETA-BOSWELLIC ACID USP/EP/BP

Urs-12-en-23-oic acid,3-hydroxy-11-oxo-, (3a,4b)-

11-Oxo-β-boswellic acid

Pharoxifene

Raloxifenum

β-Boswellic acid,11-keto

17019-92-0

Apoptosis

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Miscellaneous Natural Products