N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- Product Name
- N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- CAS No.
- 70375-43-8
- Chemical Name
- N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- Synonyms
- SCH-202676;SCH202676 HBr;AURORA KA-7903;SCH 202676 HBr;SCH-202676 HBr;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
- CBNumber
- CB1420216
- Molecular Formula
- C15H13N3S
- Formula Weight
- 267.35
- MOL File
- 70375-43-8.mol
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Property
- Melting point:
- 240.0-240.8 °C(lit.)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO: 40 mg/mL
- form
- Yellow solid.
- color
- Beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 1400
- Product name
- SCH202676hydrobromide
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 1400
- Product name
- SCH202676hydrobromide
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $749
- Updated
- 2021/12/16
- Product number
- S200038
- Product name
- SCH-202676
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 256627
- Product name
- SCH 202676 hydrobromide
- Packaging
- 10mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- INB0000135
- Product name
- SCH-202676
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $250.95
- Updated
- 2021/12/16
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Usage,Production
Description
SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3
Uses
SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).
References
1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30 2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422 3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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