N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

Product Name: N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
CAS No.: 70375-43-8
Chemical Name: N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
Synonyms: SCH-202676;SCH202676 HBr;AURORA KA-7903;SCH 202676 HBr;SCH-202676 HBr;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;SCH-202676, GPCR allosteric modulator;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR
CBNumber: CB1420216
Molecular Formula: C15H13N3S
Formula Weight: 267.35
MOL File: 70375-43-8.mol

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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Property

Melting point:: 240.0-240.8 °C(lit.)
storage temp.: Desiccate at +4°C
solubility: DMSO: 40 mg/mL
form: Yellow solid.
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1400
Product name: SCH202676hydrobromide
Purity: ≥99%(HPLC)
Packaging: 10
Price: $181
Updated: 2021/12/16

Tocris

Product number: 1400
Product name: SCH202676hydrobromide
Purity: ≥99%(HPLC)
Packaging: 50
Price: $749
Updated: 2021/12/16

TRC

Product number: S200038
Product name: SCH-202676
Packaging: 10mg
Price: $95
Updated: 2021/12/16

Usbiological

Product number: 256627
Product name: SCH 202676 hydrobromide
Packaging: 10mg
Price: $438
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000135
Product name: SCH-202676
Purity: 95.00%
Packaging: 10MG
Price: $250.95
Updated: 2021/12/16

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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Usage,Production

Description

SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3

Uses

SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.

Biological Activity

Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).

IC 50

Adenosine A₃ receptor

References

[1] A B FAWZI. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.[J]. Molecular Pharmacology, 2001, 59 1: 30-37. DOI:10.1124/mol.59.1.30
[2] ANNA M LEWANDOWICZ Jarmo T L Jouko Vepsäläinen. The “allosteric modulator” SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.[J]. British Journal of Pharmacology, 2006, 147 4: 422-429. DOI:10.1038/sj.bjp.0706624
[3] ANIKÓ GÖBLYÖS. Synthesis and Biological Evaluation of a New Series of 2,3,5-Substituted [1,2,4]-Thiadiazoles as Modulators of Adenosine A1 Receptors and Their Molecular Mechanism of Action[J]. Journal of Medicinal Chemistry, 2005, 48 4: 1145-1151. DOI:10.1021/jm049337s

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Suppliers

Austria 1 China 35 Germany 2 Switzerland 1 United Kingdom 1 United States 10 Global 50

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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Enzo Biochem Inc

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Biosynth Biological Technology (Suzhou) Co Ltd

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Santa Cruz Biotechnology Inc

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70375-43-8, N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDERelated Search:

Prostaglandin E2 Bromocriptine mesylate Rimonabant (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

AURORA KA-7903

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

SCH-202676

SCH 202676 HYDROBROMIDE

Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-

SCH 202676 HBr

SCH202676 HBr

SCH-202676 HBr

SCH 202676 HBr,SCH202676 HBr

SCH-202676, GPCR allosteric modulator

70375-43-8

C15H16BrN3S

C15H13N3SHBr

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Reagents

G Proteins and Cyclic Nucleotides

G Protein Function

G-Protein