ChemicalBook > CAS DataBase List > N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

Product Name
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
CAS No.
70375-43-8
Chemical Name
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
Synonyms
SCH-202676;SCH202676 HBr;AURORA KA-7903;SCH 202676 HBr;SCH-202676 HBr;SCH 202676 HYDROBROMIDE;SCH 202676 HBr,SCH202676 HBr;SCH-202676, GPCR allosteric modulator;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR
CBNumber
CB1420216
Molecular Formula
C15H13N3S
Formula Weight
267.35
MOL File
70375-43-8.mol
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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Property

Melting point:
240.0-240.8 °C(lit.)
storage temp. 
Desiccate at +4°C
solubility 
DMSO: 40 mg/mL
form 
Yellow solid.
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1400
Product name
SCH202676hydrobromide
Purity
≥99%(HPLC)
Packaging
10
Price
$181
Updated
2021/12/16
Tocris
Product number
1400
Product name
SCH202676hydrobromide
Purity
≥99%(HPLC)
Packaging
50
Price
$749
Updated
2021/12/16
TRC
Product number
S200038
Product name
SCH-202676
Packaging
10mg
Price
$95
Updated
2021/12/16
Usbiological
Product number
256627
Product name
SCH 202676 hydrobromide
Packaging
10mg
Price
$438
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000135
Product name
SCH-202676
Purity
95.00%
Packaging
10MG
Price
$250.95
Updated
2021/12/16
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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties,Usage,Production

Description

SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3

Uses

SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.

Biological Activity

Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M).

IC 50

Adenosine A3 receptor

References

[1] A B FAWZI. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.[J]. Molecular Pharmacology, 2001, 59 1: 30-37. DOI:10.1124/mol.59.1.30
[2] ANNA M LEWANDOWICZ  Jarmo T L  Jouko Vepsäläinen. The “allosteric modulator” SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.[J]. British Journal of Pharmacology, 2006, 147 4: 422-429. DOI:10.1038/sj.bjp.0706624
[3] ANIKÓ GÖBLYÖS. Synthesis and Biological Evaluation of a New Series of 2,3,5-Substituted [1,2,4]-Thiadiazoles as Modulators of Adenosine A1 Receptors and Their Molecular Mechanism of Action[J]. Journal of Medicinal Chemistry, 2005, 48 4: 1145-1151. DOI:10.1021/jm049337s

N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Suppliers

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70375-43-8, N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDERelated Search:

Prostaglandin E2 Bromocriptine mesylate Rimonabant (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

  • AURORA KA-7903
  • N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR
  • N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
  • SCH-202676
  • SCH 202676 HYDROBROMIDE
  • Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-
  • SCH 202676 HBr
  • SCH202676 HBr
  • SCH-202676 HBr
  • SCH 202676 HBr,SCH202676 HBr
  • SCH-202676, GPCR allosteric modulator
  • 70375-43-8
  • C15H16BrN3S
  • C15H13N3SHBr
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Reagents
  • G Proteins and Cyclic Nucleotides
  • G Protein Function
  • G-Protein