Diethyl cyanophosphonate

Product Name: Diethyl cyanophosphonate
CAS No.: 2942-58-7
Chemical Name: Diethyl cyanophosphonate
Synonyms: DEPC;DIETHYL PHOSPHOROCYANIDATE;DIETHYL CYANOPHOSPHATE;(ETO)2P(O)CN;Diethypyrocarbonate;DIETHYLPHOSPHORYL CYANIDE;Diethoxyphosphorylformonitrile;Diethyl cyanophospho;DIETHYL CYANOPHOSPHONATE;Diethyl cyanidophosphate
CBNumber: CB1420852
Molecular Formula: C5H10NO3P
Formula Weight: 163.11
MOL File: 2942-58-7.mol

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Diethyl cyanophosphonate Property

Boiling point:: 104-105 °C19 mm Hg(lit.)
Density: 1.075 g/mL at 25 °C(lit.)
refractive index: n20/D 1.403(lit.)
Flash point:: 177 °F
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
form: Liquid
Specific Gravity: 1.075
color: Clear colorless to yellow
Water Solubility: DECOMPOSES
Sensitive: Moisture Sensitive
BRN: 1768938
Exposure limits: NIOSH: IDLH 25 mg/m3
Stability:: Moisture Sensitive
CAS DataBase Reference: 2942-58-7(CAS DataBase Reference)
NIST Chemistry Reference: Diethyl cyanophosphonate(2942-58-7)

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Safety

Hazard Codes: C,Xi,T+
Risk Statements: 34-32-26/27/28
Safety Statements: 26-36-45-50A-36/37/39-28A-36/37-28
RIDADR: UN 2922 8/PG 2
WGK Germany: 3
RTECS: TD2500000
F: 10-13-21
Hazard Note: Irritant
HazardClass: 8
PackingGroup: II
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1242
Product name: Diethyl Cyanophosphonate
Purity: >95.0%(GC)
Packaging: 5g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: C1242
Product name: Diethyl Cyanophosphonate
Purity: >95.0%(GC)
Packaging: 25g
Price: $228
Updated: 2024/03/01

Alfa Aesar

Product number: L14107
Product name: Diethyl cyanophosphonate, tech. 90%
Packaging: 5g
Price: $43.5
Updated: 2021/12/16

Alfa Aesar

Product number: L14107
Product name: Diethyl cyanophosphonate, tech. 90%
Packaging: 25g
Price: $125
Updated: 2021/12/16

TRC

Product number: D444195
Product name: Diethyl cyanophosphonate
Packaging: 5g
Price: $275
Updated: 2021/12/16

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Diethyl cyanophosphonate Chemical Properties,Usage,Production

Chemical Properties

Diethyl cyanophosphonate is a clear colourless to yellow liquid. It soluble in most common organic solvents , such as dimethylformamide , tetrahydrofuran , diethyl ether , and toluene. Diethyl cyanophosphonate is highly toxic and corrosive. lt must be handled in awell-ventilated fume hood. In addition, it is moisture sensitive and should bestored in a refrigerator under nitrogen.

Uses

Diethyl cyanophosphonate was used in the synthesis of 4-acylthiol-4-deoxy-4′-demethyl epipodophyllotoxin analogs. Coupling reagent for peptide synthesis. Reagent for the phosphorylation of phenols. Activating agent for fluorescent derivatization of carboxylic acids which allows separation by HPLC.

Application

1973 Harusawa et al. found that diethyl phosphorocyanidate (diethyl cyanophosphonate; depc), a cyano and diethyl analog of DPPA, was a valuable reagent for peptide synthesis. DEPC is a practical and versatile reagent for organic synthesis, particularly as a condensing reagent for the synthesis of amides and peptides and its application in O-, S-, and C-acylations. Compared to other cyanating agents, DEPC is significantly less toxic and commercially available. DEPC can also be employed as a cyanating agent for introducing a C1 unit into a range of compounds, and its reaction with carbonyl compounds in the presence of a catalyst easily affords CPs, which are key intermediates in a variety of reactions[1].

General Description

Diethyl cyanophosphonate (DCNP, a Tabun mimic, DECP) is a nerve agent simulant. Its detection by using fluorescein, a reversible fluorescent sensor, has been reported. Its degradation in the presence of suitable organocatalysts (different amines, aminoalcohols and glycols) has been studied.

References

[1] Shinya Harusawa , Takayuki Shioiri. “Diethyl phosphorocyanidate (DEPC): a versatile reagent for organic synthesis.” Tetrahedron 72 50 (2016): Pages 8125-8200.

Diethyl cyanophosphonate Preparation Products And Raw materials

Raw materials

DIETHYL PHOSPHATE Cyanogen bromide

Preparation Products

Foscarnet sodium

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Diethyl cyanophosphonate Suppliers

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Aladdin Scientific

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View Lastest Price from Diethyl cyanophosphonate manufacturers

R&D Scientific Inc.

Product: Diethyl Cyanophosphonate 2942-58-7
Price: US $2800.00/Kg
Min. Order: 1Kg
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-07-11

Hebei Weibang Biotechnology Co., Ltd

Product: Diethyl cyanophosphonate 2942-58-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-01-11

Career Henan Chemical Co

Product: Diethyl cyanophosphonate 2942-58-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

2942-58-7, Diethyl cyanophosphonateRelated Search:

Mefenpyr-diethyl Acetonitrile DIETHYL ETHYLPHOSPHONATE Triethyl phosphate Diethyl cyanomethylphosphonate Diethyl phthalate Triethyl phosphite Ethyl cyanoacetate Diethyl malonate Diethyl phosphite Ethyl N-cyanoethanimideate DIETHYL PHOSPHATE ETHYL 2-CYANOACRYLATE Diethyl carbonate Diethyl methylphosphonate Diethyl ether HYDROGEN CYANIDE METHYLPHOSPHONIC ACID

DIETHYL PHOSPHOROCYANIDATE

DIETHYLPHOSPHORYL CYANIDE

DIETHYL CYANOPHOSPHATE

DIETHYL CYANOPHOSPHONATE

CYANOPHOSPHONIC ACID DIETHYL ESTER

(ETO)2P(O)CN

Diethoxy-phosphoryl cyanide

diethoxy-phosphorylcyanide

Diethyl cyanidophosphate

Diethyl cyanophosphosphonate

diethylcyanophosphosphonate

Phosphorocyanidic acid, diethyl ester

Phosphorocyanidic acid, O,O-diethyl ester

phosphorocyanidicacid,o,o-diethylester

DEPC DIETHYLCYANOPHOSPHONATE

DEPC (Diethyl phosphoryl cyanide)

Diethypyrocarbonate

DIETHYL CYANOPHOSPHONATE: TECH., 90%

DEPC

Diethoxyphosphorylformonitrile

Diethyl cyanophosphonate,93%

Diethylcyanophosphonic acid

Diethyl cyanophosphonate(DEPC)

Diethyl cyanophosphonate, 93% 25GR

Diethyl cyanophosphonate, 93% 5GR

Diethyl cyanophospho

Diethyl phosphorocyanidoate, (Diethoxyphosphoryl)cyanide

Cyanophosphonic Acid Diethyl Ester Diethyl Phosphorocyanidate

(Diethoxyphosphoryl)cyanide, Diethyl cyanophosphonate

Diethyl cyanophosphonate 90%

Diethyl cyanophosphonate, technical, 90%

Diethylecyanophosphonate

Diethyl Cyanophosphonate &gt

iethoxyphosphorylformonitrile

2942-58-7

220-936-5

CH3CH2O2POCN

C5H10NO3P

Organic Building Blocks

Phosphonates/Phosphinates

Phosphorus Compounds

Peptide Synthesis

Coupling Reactions (Peptide Synthesis)

Condensation & Active Esterification

Building Blocks

Biochemistry

Condensation & Active Esterification

Coupling Reactions (Peptide Synthesis)

Peptide Synthesis

Synthetic Organic Chemistry