ChemicalBook > CAS DataBase List > L-2-Chlorophenylglycine

L-2-Chlorophenylglycine

Product Name
L-2-Chlorophenylglycine
CAS No.
141315-50-6
Chemical Name
L-2-Chlorophenylglycine
Synonyms
(R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID;NSC63256;ST5452327;-(+)-2-(2-ChL;Clopidogrel-10;NCIOpen2_000290;Clopidogrel Impurity 66;Clopidogrel Impurities3;(S)-2-Chorophenylglycine;L-(2-CHLOROPHENYL)GLYCINE
CBNumber
CB1422058
Molecular Formula
C8H8ClNO2
Formula Weight
185.61
MOL File
141315-50-6.mol
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L-2-Chlorophenylglycine Property

Melting point:
182-187 °C(lit.)
Boiling point:
318.8±32.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
pka
1.69±0.10(Predicted)
color 
White to off-white
optical activity
[α]/D 79.0 to 90.0°, c =1 in methanol
[α]20/D +79°, c =1% in chloroform
CAS DataBase Reference
141315-50-6(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
638943
Product name
L-(+)-2-Chlorophenylglycine
Purity
95%
Packaging
5G
Price
$156
Updated
2023/06/20
TCI Chemical
Product number
C2431
Product name
L-(+)-2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$44
Updated
2021/12/16
TCI Chemical
Product number
C2431
Product name
L-(+)-2-(2-Chlorophenyl)glycine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$132
Updated
2021/12/16
TRC
Product number
C350555
Product name
L-2-Chlorophenylglycine
Packaging
25g
Price
$65
Updated
2021/12/16
Usbiological
Product number
453125
Product name
L-2-Chlorophenylglycine
Packaging
100mg
Price
$305
Updated
2021/12/16
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L-2-Chlorophenylglycine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

L-2-Chlorophenylglycine

Synthesis

143-33-9

89-98-5

86169-24-6

The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde is as follows: 2-chlorophenylglycine was prepared according to the synthetic method described in Scheme 1. This was done as follows: 2-chlorobenzaldehyde, ammonium bicarbonate (NH4HCO3; 23.7 g) and sodium cyanide (NaCN; 14.7 g) were dissolved in a mixed solution of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4).Subsequently, the precipitate was collected by filtration and washed with distilled water to give a final product of 27 g (58% yield) of 2-chlorophenylglycine. The compound had a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C.

References

[1] Patent: US2004/176637, 2004, A1. Location in patent: Page 3

L-2-Chlorophenylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-2-Chlorophenylglycine manufacturers

Career Henan Chemical Co
Product
L-2-Chlorophenylglycine 141315-50-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

141315-50-6, L-2-ChlorophenylglycineRelated Search:

2-Chlorobenzoyl chloride 2-(2-Chlorophenyl)acetonitrile 2-Chlorophenol Glycine 2'-Chloroacetophenone Sodium glycinate ALTRENOGEST 2-Chlorobenzonitrile 2-Chlorobenzaldehyde L-Phenylglycine 4-Hydroxy-D-(-)-2-phenylglycine 2-Chlorobenzoic acid Ethyl 2-(Chlorosulfonyl)acetate 6-Aminocaproic acid 4-Aminophenylacetic acid α-Lipoic Acid D-2-Phenylglycine Sodium hydroxymethylglycinate

  • (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
  • (S)-(+)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-A-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-2-CHLOROPHENYLGLYCINE
  • S-(+)-2-(2-CHLORO PHENYL)GLYCINE
  • L-(+)-2-CHLOROPHENYLGLYCINE
  • L-(2-CHLOROPHENYL)GLYCINE
  • (L)-(-)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-(+)-(o-Chlorophenyl)glycine
  • 1-(+)-2-chlorophenylglycine
  • (2S)-amino(2-chlorophenyl)ethanoic acid
  • L(+)-O-CHLOROPHENYLGLYCINE
  • Amino chlorophenyl acetic acid
  • (S)-2-Chorophenylglycine
  • (S)-2-Chlorophenylglycinol
  • L-(+)-2-Chlorophenylglycine,(S)-αAmino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine
  • L-(+)-chlorophenyl glycine
  • L-(+)-2-(2-Chlorophenyl)glycine
  • (R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID
  • (S)-α-Amino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine
  • Clopidogrel-10
  • (+)-2-Chloro-L-phenylglycine, 95%
  • L-2-Chlorophenylglycine (S)-alpha-Amino-(2-chlorophenyl)acetic acid
  • Benzeneacetic acid, .alpha.-amino-2-chloro-, (.alpha.S)-
  • Benzeneacetic acid, a-amino-2-chloro-, (aS)-
  • L-(+)-2-Chlorophenylglycine 95%
  • 2-[(2-chlorophenyl)amino]ethanoic acid
  • N-(2-chlorophenyl)glycine
  • NCIOpen2_000290
  • NSC63256
  • ST5452327
  • <small>L</small>-(+)-2-(2-Chlorophenyl)glycine
  • Benzeneacetic acid, α-amino-2-chloro-, (αS)-
  • (2S)-2-azaniumyl-2-(2-chlorophenyl)acetate
  • Clopidogrel Impurity 66
  • L-(+)-2-(2-Chlorophenyl)glycine &gt
  • (+)-2-Chloro-L-phenylglycine
  • -(+)-2-(2-ChL
  • (S)-2-Amino-2-(2-chlorophenyl)aceticaci
  • 2-Chloro-L-(+)-2-phenylglycine
  • L-2-Chlorophenylglycine USP/EP/BP
  • (S)-2-Amino-2-(2-chlorophenyl)acetic acid (Clopidogrel Impurity)
  • Clopidogrel Impurities192
  • Clopidogrel Impurities3
  • Clopidogrel EP Impurity 26
  • <sc>L</sc>-(+)-2-Chlorophenylglycine
  • 141315-50-6
  • ClC6H4CHNH2CO2H
  • C8ClH8NO2
  • C9H8INO2
  • Carboxylic acid
  • Peptide Synthesis
  • Phenylglycine Derivatives
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Amino ACIDS SERIES
  • pharmacetical
  • chiral