O-1918
- Product Name
- O-1918
- CAS No.
- 536697-79-7
- Chemical Name
- O-1918
- Synonyms
- O-1918;1,3-DIMETHOXY-5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-BENZENE;Benzene, 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-
- CBNumber
- CB1422902
- Molecular Formula
- C19H26O2
- Formula Weight
- 286.41
- MOL File
- 536697-79-7.mol
O-1918 Property
- Boiling point:
- 383.9±42.0 °C(Predicted)
- Density
- 0.981±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
N-Bromosuccinimide Price
- Product number
- 10004914
- Product name
- O-1918
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 10004914
- Product name
- O-1918
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 10004914
- Product name
- O-1918
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 10004914
- Product name
- O-1918
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $315
- Updated
- 2024/03/01
- Product number
- 2288
- Product name
- O-1918
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
O-1918 Chemical Properties,Usage,Production
Uses
O-1918 is a cannabidiol analog and a selective antagonist at the endothelial cannabidiol receptor. It is an inhibitor of GPR18. O-1918 can also induce endothelium-dependent vasodilation.
Biological Activity
Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB 1 or CB 2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol).
Enzyme inhibitor
This endocannabinoid antagonist (FW = 286.42 g/mol; CAS 536697-79-7), systematically named 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1- methylethenyl)-2-cyclohexen-1-yl]benzene, is a cannabidinodiol analogue that selectively targets a putative G-coupled endothelial anandamide receptor that is distinct from CB1 or CB2 endocannabinoid receptors. O- 1918 does not bind to CB1 or CB2 receptors and does not cause vasorelaxation at concentrations up to 30 μM, but inhibits the vasorelaxant effects of abn-cbd and anandamide in a concentration-dependent manner (1- 30 μM). (See abn-cbd; Anandamide; Oleamide). While the atypical cannabinoids O-1602 and abn-cbd (or abnormal cannabidiol) stimulate GPR55-dependent GTPgS activity (EC50 ~ 2 nM), O-1918 antagonizes such effects. O-1918 is involved in the delayed hypotension induced by anandamide in anaesthetized rats.
storage
Store at -20°C