OLTIPRAZ
- Product Name
- OLTIPRAZ
- CAS No.
- 64224-21-1
- Chemical Name
- OLTIPRAZ
- Synonyms
- CD1400;OLTIPRAZ;RP-35972;NSC 347901;CCRIS 4048;BRN 0978110;OLTIPRAZ USP/EP/BP;Oltipraz (RP 35972;64224-21-1 OLTIPRAZ;Oltipraz (NSC-347901)
- CBNumber
- CB1431766
- Molecular Formula
- C8H6N2S3
- Formula Weight
- 226.34
- MOL File
- 64224-21-1.mol
OLTIPRAZ Property
- Melting point:
- 165-166
- Boiling point:
- 408.1±55.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- RTECS
- JP1293000
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- pka
- 0.18±0.10(Predicted)
- form
- Solid
- color
- red
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- CKNAQFVBEHDJQV-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O9389
- Product name
- Oltipraz
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- O9389
- Product name
- Oltipraz
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $434
- Updated
- 2024/03/01
- Product number
- H35120
- Product name
- 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione
- Packaging
- 100mg
- Price
- $149.65
- Updated
- 2024/03/01
- Product number
- H35120
- Product name
- 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione
- Packaging
- 500mg
- Price
- $456.65
- Updated
- 2024/03/01
- Product number
- 15118
- Product name
- Oltipraz
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $97
- Updated
- 2024/03/01
OLTIPRAZ Chemical Properties,Usage,Production
Description
Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice.1 Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis.2 Oltipaz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.3 Promotes liver regeneration after partial hepatectomy.4 Off target effects: Activates constitutive androstane receptor (CAR).5
Chemical Properties
Dark Red Solid
Uses
Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes.
Uses
schistosomicide, antineoplastic
Uses
Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxi fication enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes.
Definition
ChEBI: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
General Description
Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.
Biochem/physiol Actions
Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.
storage
Store at +4°C
References
1) Yu?et al. (2011),?Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice; Diabetologia,?54?922 2) Shimozono?et al. (2013),?Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model; Mol. Pharmacol,?84?62 3) Eba?et al. (2013),?The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice; Am. J. Respir. Cell. Mol. Biol.,?49?324 4) Cho?et al. (2009), Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kinase dependent C/EBPbeta and cyclin E regulation; Arch. Pharm. Res.,?32?625 5) Merrell?et al. (2008),?The Nrf2 activator oltipraz also activates the constitutive androstane receptor; Drug Metab. Dispos.,?36?1716
OLTIPRAZ Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from OLTIPRAZ manufacturers
- Product
- oltipraz 64224-21-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- OLTIPRAZ 64224-21-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-18
- Product
- Oltipraz 64224-21-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 tons
- Release date
- 2020-04-27