OLTIPRAZ

Product Name: OLTIPRAZ
CAS No.: 64224-21-1
Chemical Name: OLTIPRAZ
Synonyms: CD1400;OLTIPRAZ;RP-35972;NSC 347901;CCRIS 4048;BRN 0978110;OLTIPRAZ USP/EP/BP;Oltipraz (RP 35972;64224-21-1 OLTIPRAZ;Oltipraz (NSC-347901)
CBNumber: CB1431766
Molecular Formula: C8H6N2S3
Formula Weight: 226.34
MOL File: 64224-21-1.mol

More

Less

OLTIPRAZ Property

Melting point:: 165-166
Boiling point:: 408.1±55.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
RTECS: JP1293000
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
pka: 0.18±0.10(Predicted)
form: Solid
color: red
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey: CKNAQFVBEHDJQV-UHFFFAOYSA-N

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O9389
Product name: Oltipraz
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: O9389
Product name: Oltipraz
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $434
Updated: 2024/03/01

Alfa Aesar

Product number: H35120
Product name: 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione
Packaging: 100mg
Price: $149.65
Updated: 2024/03/01

Alfa Aesar

Product number: H35120
Product name: 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione
Packaging: 500mg
Price: $456.65
Updated: 2024/03/01

Cayman Chemical

Product number: 15118
Product name: Oltipraz
Purity: ≥98%
Packaging: 100mg
Price: $97
Updated: 2024/03/01

More

Less

OLTIPRAZ Chemical Properties,Usage,Production

Description

Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice.1 Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis.2 Oltipaz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.3 Promotes liver regeneration after partial hepatectomy.4 Off target effects: Activates constitutive androstane receptor (CAR).5

Chemical Properties

Dark Red Solid

Uses

Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes.

Uses

schistosomicide, antineoplastic

Definition

ChEBI: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.

General Description

Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.

Biochem/physiol Actions

Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.

storage

Store at +4°C

References

1) Yu?et al. (2011),?Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice; Diabetologia,?54?922 2) Shimozono?et al. (2013),?Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model; Mol. Pharmacol,?84?62 3) Eba?et al. (2013),?The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice; Am. J. Respir. Cell. Mol. Biol.,?49?324 4) Cho?et al. (2009), Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kinase dependent C/EBPbeta and cyclin E regulation; Arch. Pharm. Res.,?32?625 5) Merrell?et al. (2008),?The Nrf2 activator oltipraz also activates the constitutive androstane receptor; Drug Metab. Dispos.,?36?1716

OLTIPRAZ Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

OLTIPRAZ Suppliers

Canada 1 China 110 Europe 1 Germany 1 India 4 United Kingdom 5 United States 17 Global 139

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

More

Less

View Lastest Price from OLTIPRAZ manufacturers

Honest Joy Holdings Limited

Product: oltipraz 64224-21-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.2%
Supply Ability: 100 tons
Release date: 2022-01-14

Dideu Industries Group Limited

Product: OLTIPRAZ 64224-21-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-18

Shaanxi Dideu Medichem Co. Ltd

Product: Oltipraz 64224-21-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 tons
Release date: 2020-04-27

64224-21-1, OLTIPRAZRelated Search:

AR-A014418 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Andrographolide CHIR-99021 Sodium Pyrithione Zinc pyrithione FLAVONE Polyphenol 2-Mercaptomethylpyrazine 2-VINYLPYRAZINE OLTIPRAZ

NSC 347901

3H-1,2-Dithiole-3-thione,4-methyl-5-(2-pyrazinyl)-

OLTIPRAZ

4-methyl-5-pyrazinyl-3h-1,2-dithiole-3-thione

4-methyl-5-pyrazinyl-3h-2-dithiole-3-thione

5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione

4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione

RP-35972

4-methyl-5-pyrazin-2-yl-1,2-dithiole-3-thione

4-methyl-5-pyrazin-2-yl-dithiole-3-thione

4-methyl-5-pyrazin-2-yldithiole-3-thione

4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione

BRN 0978110

CCRIS 4048

Oltipraz (NSC-347901)

OLTIPRAZ USP/EP/BP

Oltipraz (RP 35972

64224-21-1 OLTIPRAZ

CD1400

3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-

64224-21-1

C8H6N2S3