Product description Uses Pharmaceutical Applications Efficacy Photolysis Toxicity evaluation
ChemicalBook > CAS DataBase List > Zinc pyrithione

Zinc pyrithione

Product description Uses Pharmaceutical Applications Efficacy Photolysis Toxicity evaluation
Product Name
Zinc pyrithione
CAS No.
13463-41-7
Chemical Name
Zinc pyrithione
Synonyms
ZPT;Pyrithione zinc;ZNPT;Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt;zincpt;OM-1563;vancidep;zincpyrion;de-squaman;vancide zp
CBNumber
CB6456070
Molecular Formula
C10H8N2O2S2Zn
Formula Weight
317.7
MOL File
13463-41-7.mol
More
Less

Zinc pyrithione Property

Melting point:
approximate 240℃
Density 
1.782 g/cm3(Temp: 25 °C)
vapor pressure 
0Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Pyridine
form 
Powder
color 
White to Orange to Green
Odor
Mild Characteristic
Water Solubility 
Insoluble (<0.1 g/100 mL at 21 ºC)
Merck 
14,7994
InChI
InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
InChIKey
OTPSWLRZXRHDNX-UHFFFAOYSA-L
SMILES
C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-]
LogP
0.9 at 25℃ and pH7.5-7.7
Surface tension
73mN/m at 7.22mg/L and 20℃
CAS DataBase Reference
13463-41-7(CAS DataBase Reference)
EPA Substance Registry System
Zinc pyrithione (13463-41-7)
More
Less

Safety

Hazard Codes 
T+,N,T
Risk Statements 
24/25-26-37/38-41-50/53-23-22
Safety Statements 
26-28-36/37/39-45-61-60-39
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
ZH0950000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29333990
Hazardous Substances Data
13463-41-7(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 177mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H330Fatal if inhaled

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6377
Product name
1-Hydroxypyridine-2-thione zinc salt
Purity
≥95%
Packaging
10g
Price
$87.4
Updated
2024/03/01
Sigma-Aldrich
Product number
H6377
Product name
1-Hydroxypyridine-2-thione zinc salt
Purity
≥95%
Packaging
100g
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
M0633
Product name
2-Mercaptopyridine N-Oxide Zinc Salt
Purity
>98.0%(T)
Packaging
25g
Price
$99
Updated
2024/03/01
TCI Chemical
Product number
M0633
Product name
2-Mercaptopyridine N-Oxide Zinc Salt
Purity
>98.0%(T)
Packaging
100g
Price
$269
Updated
2024/03/01
Cayman Chemical
Product number
29154
Product name
Zinc Pyrithione
Packaging
25g
Price
$95
Updated
2023/06/20
More
Less

Zinc pyrithione Chemical Properties,Usage,Production

Product description

Zinc pyrithione is the pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent. At room temperature it is white to yellow crystalline powder. Slight characteristic odor. Insoluble in water. Solubility: water 15mg/kg; pH = 8 Water 35mg/kg; Ethanol 100mg/kg; polyethylene glycol (PEG400) 2000mg/kg. A pH optimum range of 4.5 to 9.5; mass fraction of 10% suspension pH3.6. Zinc pyrithione react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,it is not stable to acids and bases . It is not compatible with EDTA, non-ionic surfactants make it partially deactivated. When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water.
EEC and GB7916-87 provide that maximum allowable concentration of mass fraction of zinc pyrithione on cosmetics is 0.5%, only for cleaning after using products.General concentration 250~1000mg/kg (active), zinc pyrithione can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.

Uses

Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide.
Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff .

Pharmaceutical Applications

Zinc pyrithione is a regulator of keratinization, selenium sulfide has antimicrobial properties and ketoconazole is an antifungal agent (i.e.can provide the reduction of the lipophilic yeast Malassezia furfur).

Efficacy

Zinc pyrithione shampoos (in concentrations between 1 to 2%) and shampoos with selenium sulide have been reported to be effective in the treatment of scalp psoriasis.However,their efficacy has not been substantiated by controlled studies.There is also some evidence that shampoos with antifungal agents (e.g.ketoconazole)can have a beneficial effect on scalp conditions. It should be noted, however, that the effectiveness of these shampoos is much smaller than these containing tars, corticosteroids or keratolytics.

Photolysis

Zinc pyrithione is very rapidly transformed by photolysis. Experiments conducted under sterile conditions with a light:dark cycle of 12:12 hours have shown that, under exposure to light, the concentration of [pyridine-2,6-14C]zinc pyrithione in pH 9 buffer was reduced to 33% of the radioactivity added in 15 min. Data from this study also demonstrated that less than 5% of the 14C added occurred as zinc pyrithione after 1 hour of exposure to light. Similar results have been achieved when photolysis of zinc pyrithione was investigated by use of artificial seawater. In this study, the parent compound constituted 45% of the radioactivity added after 15 min while, after 24 hours, 1.3% of the added dose occurred as zinc pyrithione. The estimated half-lives of the photolytic transformation of zinc pyrithione was 13 min in pH 9 buffer and 17.5 min in artificial seawater (Reynolds 1995a).
https://www2.mst.dk/udgiv/publications/2000/87-7944-084-3/html/kap04_eng.htm

Toxicity evaluation

The toxicity of the active substance zinc pyrithione has been investigated in standard laboratory tests with a number of aquatic organisms living in fresh water (the green alga Selenastrum capricornutum, the crustacean Daphnia magna, the fish rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas)) and in seawater (the crustacean Mysidopsis bahia, the fish sheepshead minnow (Cyprinodon variegatus) and the oyster (Crassostrea virginica)) (Boeri et al. 1993; 1994a-e; Ward et al. 1994a).
The results show that while zinc pyrithione and omadine disulfide were very toxic to aquatic organisms (L(E)C50 in the order of 3-300 µg/L), omadine sulfonic acid and pyridine sulfonic acid were considerably less toxic (L(E)C50 in the order of >20 mg/L) (Olin 1977). In a long-term study with fish eggs and larvae, pyridine sulfonic acid gave no effects at a concentration of 0.01 mg/L (Boeri et al. 1999). Algae were the group of organisms most sensitive to the last two substances.

Description

Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.

Chemical Properties

Beige granules

Uses

zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder.

Uses

Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.

Uses

Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.

Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.

Indications

Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.

brand name

Head & Shoulders Conditioner (Procter & Gamble).

General Description

Fine beige granules.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.

Fire Hazard

Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.

Contact allergens

Zinc pyrithione is widely used in antidandruff shampoos and is a classic allergen. Concomitant reactions are expected to both zinc and sodium pyrithione.

Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx, SOx, and ZnO. Used as an anti- dandruff agent in shampoos. See also ZINC COMPOUNDS and SULFIDES.

Synthesis

1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %.

Zinc pyrithione Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Zinc pyrithione Suppliers

Langfang gehui Chemical Products Co., Ltd.
Tel
0316-0316-2574366 18632616626
Fax
0316-2574366
Email
546994510@qq.com
Country
China
ProdList
11
Advantage
58
Xi'an Kono chem co., Ltd.
Tel
29-84385017-8016 15891718909
Fax
15891718909
Email
sales@konochemical.com
Country
China
ProdList
141
Advantage
58
Kono Chem Co.,Ltd
Tel
029-86107037-8009 13279399072
Fax
13279399072
Email
info@konochemical.com
Country
China
ProdList
603
Advantage
58
NANJING SUNSHINE BIOTECH CO.,LTD
Tel
025-86189919,025-86189929 13814179829
Fax
86-25-86189616
Email
market@sunshine-bio.com
Country
China
ProdList
48
Advantage
58
Wuhan pushida biotechnology co., Ltd
Tel
18163336578
Email
2139086656@qq.com
Country
China
ProdList
1448
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
More
Less

View Lastest Price from Zinc pyrithione manufacturers

Jinan Finer Chemical Co., Ltd
Product
Zinc pyrithione (ZPT) 13463-41-7
Price
US $0.00/Kg/Drum
Min. Order
100g
Purity
99%
Supply Ability
1000mt
Release date
2020-08-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Zinc Pyrithione 13463-41-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-04-19
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Pyrithione Zinc 13463-41-7
Price
US $80.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-06-04

13463-41-7, Zinc pyrithioneRelated Search:


  • 1-HYDROXY-2-PYRIDINE THIONE, ZN SALT
  • 1-HYDROXYPYRIDINE-2-THIONE ZINC
  • Pyrithione zincique
  • Bis[(1-oxylatopyridinium)-2-ylthio] zinc
  • Bis[(1-oxylatopyridinium-2-yl)thio]zinc
  • Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt
  • Bis(2-pyridylthio) Zinc 1,1'-Dioxide 1-Hydroxypyridine-2-thione Zinc Salt 2-Pyridinethiol 1-Oxide Zinc Salt Zinc Pyrithione
  • zincpolyanemine
  • zincpt
  • zincpyrethion
  • zincpyridinethione
  • zincpyrion
  • 1-hydroxypyridine-2-thione zinc(ZPT)
  • 1-Hydroxypyridine-2-thione zinc salt >=95%
  • Zinc, bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS2]-, (T-4)-
  • Zinc Pyrithione 48-50% (ZPT)
  • 1-Hydroxypyridine-2-thione zinc salt, >=97%
  • Pyrithionc Zinc, ZPT
  • Zinc pyrithione CAS 13463-41-7
  • Zinc pyridine thioneone
  • Zinc pyridine thioneone 50% suspension
  • Zinc Pyrithiazone 48
  • 1-HYDROXYPYRIDINE-2-THIONE ZINC SALT
  • 2-PYRIDINETHIOL 1-OXIDE ZINC SALT
  • BIS(1-HYDROXY-2(H)-PYRIDINETHIONATO)ZINC
  • BIS(2-PYRIDYLTHIO) ZINC 1,1'-DIOXIDE
  • de-squaman
  • SALTPYRITHIONE ZINC
  • Pyrithione zinc
  • PYRITHIONE ZINC SALT
  • omadine zinc
  • OM-1563
  • N-HYDROXYPYRIDINETHIONE ZINC SALT
  • bis(1-hydroxy-2(1h)-pyridinethionato)-zin
  • bis(1-hydroxy-2-(1h)-pyridinethionato)zinc
  • bis(1-hydroxy-2(1h)-pyridinethionato)zinc
  • bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-,(T-4)-Zinc
  • bis(2-pyridinethiol-1-oxide)zinc
  • bis-(2-sulfidopyridin-n-oxide)zinc
  • bis-(2-sulfidopyridin-n-oxide)zinc(zincomadine)
  • bis-(2-sulfidopyridin-n-oxide)zinc(zincpyrithione)
  • s)-bis(1-hydroxy-2(1h)-pyridinethionato-(beta-4)-zin
  • s)-bis(1-hydroxy-2(1h)-pyridinethionato-(t-4)-zin
  • vancidep
  • zinc,bis(2-pyridinylthio)-,n,n’-dioxide
  • zinc,bis(2-pyridylthio)-,1,1’-dioxide
  • zinc,bis(2-pyridylthio)-,n,n’-dioxide
  • zinc1-hydroxy-2-pyridinethione
  • zincomadine
  • ZNPT
  • ZPT
  • ZINC PYRETHEON
  • ZINC PYRIDINE-2-THIOL-1-OXIDE
  • ZINC PYRITHIONE
  • Zinc 2-pyridinethiol-1-oxide
  • Zinc 1-hydroxypyridine-2-thione
  • zinc 2-mercaptopyridine-n-oxide
  • vancide zp