ChemicalBook > CAS DataBase List > 1,3-Propanesultone

1,3-Propanesultone

Product Name
1,3-Propanesultone
CAS No.
1120-71-4
Chemical Name
1,3-Propanesultone
Synonyms
1,3-PROPANESULTONE;PROPANE SULTONE;1,2-OXATHIOLANE, 2,2-DIOXIDE;1,3-propanesulfonic acid lactone;tone;Propyl Sultone;1,3-propyl sultone;1,3-Propanesulfone;1,3-PS;NSC 42386
CBNumber
CB1433740
Molecular Formula
C3H6O3S
Formula Weight
122.14
MOL File
1120-71-4.mol
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1,3-Propanesultone Property

Melting point:
30-33 °C (lit.)
Boiling point:
180 °C/30 mmHg (lit.)
Density 
1.392 g/mL at 25 °C (lit.)
vapor pressure 
0.001-0.48Pa at 20-25℃
refractive index 
1.4332 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder
color 
White or Colorless to Light yellow
Water Solubility 
Slightly soluble
FreezingPoint 
30.0 to 33.0 ℃
Sensitive 
Moisture Sensitive
BRN 
109782
Stability:
Stable, but moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey
FSSPGSAQUIYDCN-UHFFFAOYSA-N
LogP
-2.86--0.28 at 20℃
CAS DataBase Reference
1120-71-4(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Oxathiolane, 2,2-dioxide(1120-71-4)
IARC
2A (Vol. 4, Sup 7, 71, 110) 2017
EPA Substance Registry System
1,3-Propane sultone (1120-71-4)
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Safety

Hazard Codes 
T
Risk Statements 
45-21/22
Safety Statements 
53-45-99
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
RP5425000
21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29349990
Hazardous Substances Data
1120-71-4(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: OTHER: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. OTS0555330,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
291250
Product name
1,3-Propanesultone
Purity
≥99%
Packaging
5g
Price
$40.9
Updated
2024/03/01
Sigma-Aldrich
Product number
291250
Product name
1,3-Propanesultone
Purity
≥99%
Packaging
25g
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
901588
Product name
1,3-Propanesultone solution
Purity
1?M in THF
Packaging
25ML
Price
$121
Updated
2023/06/20
Sigma-Aldrich
Product number
901588
Product name
1,3-Propanesultone solution
Purity
1?M in THF
Packaging
100ML
Price
$260
Updated
2022/05/15
TCI Chemical
Product number
P0324
Product name
1,3-Propanesultone
Purity
>99.0%(GC)
Packaging
25g
Price
$31
Updated
2024/03/01
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1,3-Propanesultone Chemical Properties,Usage,Production

Description

Propane sultone also known as 1,3-propane sultone was first produced in the United States in 1963. Propane sultone exists at room temperature as a colorless liquid with a foul odor or as a white crystalline solid.

Chemical Properties

1,3-Propane sultone is a white crystalline solid or a colorless liquid above 30°C. It releases a foul odor as it melts. It is readily soluble in water and many organic solvents such as ketones, esters and aromatic hydrocarbons.

Uses

1,3-Propane sultone is used as a chemical intermediate to introduce the sulfopropyl group into molecules and to confer water solubility and an anionic character to the molecules. It is used as a chemical intermediate in the production of fungicides, insecticides, cation-exchange resins, dyes, vulcanization accelerators, detergents, lathering agents, bacteriostats, and a variety of other chemicals and as a corrosion inhibitor for mild (untempered) steel.

Application

1,3-Propanesultone is a cyclic sulfonic ester mainly used to introduce a propane sulfonic functionality into the organic structure. It has been used in preparation of poly[2-ethynyl-N-(propylsulfonate)pyridinium betaine],novel poly(4-vinylpyridine) supported acidic ionic liquid catalyst,novel poly(4-vinylpyridine) supported acidic ionic liquid catalyst.
1,3-Propanesultone can be used to synthesize:
A sulfonic acid functionalized acidic ionic liquid modified silica catalyst that can be used in hydrolysis of cellulose.
Zwitterionic-type molten salts with unique ion conductive properties.
Zwitterionic organofunctional silicones by the quaternization of organic amine functional silicones.

Preparation

1,3-propane sultone is produced commercially by dehydrating gamma-hydroxy-propanesulfonic acid, which is prepared from sodium hydroxypropanesulfonate. this sodium salt is prepared by addition of sodium bisulfite to allyl alcohol.

Definition

1,3-Propane sultone is a sultone. It is used as a chemical intermediate. When heated to decomposition, it emits toxic fumes of sulfur oxides. Humans are potentially exposed to residues of 1,3-propane sultone when using products manufactured from this compound. The primary routes of potential human exposure to 1,3-propane sultone are ingestion and inhalation. Contact with this chemical can cause mild irritation of the eyes and skin. It is reasonably anticipated to be a human carcinogen.

General Description

Propanesultone is a synthetic, colorless liquid or white crystalline solid that is readily soluble in water and many organic solvents such as ketones, esters and aromatic hydrocarbons. Melting point 86°F. Releases a foul odor when melting.

Air & Water Reactions

Soluble in water [Hawley].

Reactivity Profile

1,3-Propanesultone reacts slowly with water to give 3-hydroxopropanesulfonic acid. This reaction may be accelerated by acid. May react with strong reducing agents to give toxic and flammable hydrogen sulfide.

Hazard

Possible carcinogen.

Health Hazard

Propane sultone is a carcinogen in experimental animals and a suspected human carcinogen. No human data are available. It is a carcinogen in rats when given orally, intravenously, or by prenatal exposure and a local carcinogen in mice and rats when given subcutaneously.

Flammability and Explosibility

Non flammable

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by subcutaneous route. Moderately toxic by skin contact and intraperitoneal routes. Human mutation data reported. Implicated as a human brain carcinogen. A slun irritant. When heated to decomposition it emits toxic fumes of SOx.

Potential Exposure

A potential danger to those involved in use of this chemical intermediate to introduce the sulfo- propyl group (-CH 2 CH 2 CH 2 SO 3-) into molecules of other products.

Carcinogenicity

1,3-Propane sultone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Routes and Pathways and Relevant Physicochemical Properties
Appearance: white crystalline solid or colorless liquid.
Solubilities: readily soluble in ketones, esters, and aromatic hydrocarbons; insoluble in aliphatic hydrocarbons; and soluble in water (100 g l-1).
Partition Behavior in Water, Sediment, and Soil If 1,3-propane sultone is released to soil, it will be expected to rapidly hydrolyze if the soil is moist, based upon the rapid hydrolysis observed in aqueous solution. Since it rapidly hydrolyzes, adsorption to and volatilization from moist soil are not expected to be significant processes, although no data specifically regarding the fate of 1,3-propane sultone in soil were located. If released into water, it will be expected to rapidly hydrolyze. The produce of hydrolysis is 3-hydroxy- 1-propansulfonic acid. Since it rapidly hydrolyzes, bioconcentration, volatilization, and adsorption to sediment and suspended solids are not expected to be significant processes. If released to the atmosphere, it will be susceptible to photooxidation via vapor-phase reaction with photochemically produced hydroxyl radicals with a half-life of 8 days estimated for this process.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Toxicity evaluation

The reaction of propane sultone with guanosine and DNA at pH 6–7.5 gave an N7-alkylguanosine as the main product (>90%). Similar evidence suggested that two of the minor adducts were N1- and N6-alkyl derivatives, accounting for approximately 1.6 and 0.5% of the total adducts, respectively. N7- and N1-alkylguanine were also detected in the DNA reacted with propane sultone.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

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View Lastest Price from 1,3-Propanesultone manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
1,3-Propane sultone 1120-71-4
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-05
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1,3-PS 1120-71-4
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-24
Hubei Lidu New Material Technology Co., Ltd
Product
1,3-PROPANESULTONE 1120-71-4
Price
US $0.00-0.00/g
Min. Order
100g
Purity
95%
Supply Ability
20tons
Release date
2024-09-24

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