6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE

Product Name: 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
CAS No.: 101622-50-8
Chemical Name: 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
Synonyms: ISO-OLOMOUCINE;OLOMOUCINE, ISO-;6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE;Ethanol, 2-[[7-Methyl-6-[(phenylMethyl)aMino]-7H-purin-2-yl]aMino]-
CBNumber: CB1435461
Molecular Formula: C15H18N6O
Formula Weight: 298.34
MOL File: 101622-50-8.mol

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6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Property

Density: 1.36
storage temp.: Store at -20°C
solubility: ≤0.3mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
form: Off-white solid.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13325
Product name: Iso-Olomoucine
Purity: ≥98%
Packaging: 5mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 13325
Product name: Iso-Olomoucine
Purity: ≥98%
Packaging: 10mg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 13325
Product name: Iso-Olomoucine
Purity: ≥98%
Packaging: 25mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 13325
Product name: Iso-Olomoucine
Purity: ≥98%
Packaging: 50mg
Price: $420
Updated: 2024/03/01

TRC

Product number: B508878
Product name: Iso-olomoucine
Packaging: 10μg
Price: $115
Updated: 2021/12/16

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6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Chemical Properties,Usage,Production

Uses

Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases.

Definition

ChEBI: 2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol is a thiopurine.

Biological Activity

iso-olomoucine is an inactive stereoisomer of the cdk5 inhibitor olomoucine.cyclin-dependent kinases (cdks) are reported to be key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, human neurodegenerative diseases, as well as the response of addictive drugs through alteration of postsynaptic dopamine receptor signaling.

in vitro

in a previous study, rat dorsal striatal synaptosomes were incubation with the cdk5 inhibitors roscovitine, olomoucine, and gw8510 or the inactive congener iso-olomoucine, which led to a rapid, concentration-dependent inhibition of specific [3h]da uptake. however, roscovitine was the only inhibitor that did not decrease [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding to dstr dats. roscovitine-induced inhibition of dstr [3h]da uptake was demonstrated by decreased maximal uptake velocity, without a change in cell-surface dat levels. moreover, roscovitine did not enhance [3h]da release mediated by either dat reverse-transport. instead, roscovitine could enhance spontaneous [3h]da outflow and inhibit dat-mediated [3h]da reaccumulation into dstr slices. additionally, in a cdk5-independent manner, iso-olomoucine was able to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (ic50 ~37 μm) [1]

IC 50

≥ 1 mm for cdk5

References

[1] price, d. a.,sorkin, a. and zahniser, n.r. cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. molecular pharmacology 76(4), 812-823 (2009).

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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101622-50-8, 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINERelated Search:

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE 7-METHYLADENINE N2,N4-DIMETHYLPYRIMIDINE-2,4-DIAMINE 2,6-Diaminopurine 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE

OLOMOUCINE, ISO-

ISO-OLOMOUCINE

Ethanol, 2-[[7-Methyl-6-[(phenylMethyl)aMino]-7H-purin-2-yl]aMino]-

6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE

101622-50-8