6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
- Product Name
- 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
- CAS No.
- 101622-50-8
- Chemical Name
- 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE
- Synonyms
- ISO-OLOMOUCINE;OLOMOUCINE, ISO-;6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE;Ethanol, 2-[[7-Methyl-6-[(phenylMethyl)aMino]-7H-purin-2-yl]aMino]-
- CBNumber
- CB1435461
- Molecular Formula
- C15H18N6O
- Formula Weight
- 298.34
- MOL File
- 101622-50-8.mol
6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Property
- Density
- 1.36
- storage temp.
- Store at -20°C
- solubility
- ≤0.3mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
- form
- Off-white solid.
N-Bromosuccinimide Price
- Product number
- 13325
- Product name
- Iso-Olomoucine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 13325
- Product name
- Iso-Olomoucine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 13325
- Product name
- Iso-Olomoucine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- 13325
- Product name
- Iso-Olomoucine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- B508878
- Product name
- Iso-olomoucine
- Packaging
- 10μg
- Price
- $115
- Updated
- 2021/12/16
6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-7-METHYLPURINE Chemical Properties,Usage,Production
Uses
Iso-olomoucine is a potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases.
Definition
ChEBI: 2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol is a thiopurine.
Biological Activity
iso-olomoucine is an inactive stereoisomer of the cdk5 inhibitor olomoucine.cyclin-dependent kinases (cdks) are reported to be key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, human neurodegenerative diseases, as well as the response of addictive drugs through alteration of postsynaptic dopamine receptor signaling.
in vitro
in a previous study, rat dorsal striatal synaptosomes were incubation with the cdk5 inhibitors roscovitine, olomoucine, and gw8510 or the inactive congener iso-olomoucine, which led to a rapid, concentration-dependent inhibition of specific [3h]da uptake. however, roscovitine was the only inhibitor that did not decrease [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding to dstr dats. roscovitine-induced inhibition of dstr [3h]da uptake was demonstrated by decreased maximal uptake velocity, without a change in cell-surface dat levels. moreover, roscovitine did not enhance [3h]da release mediated by either dat reverse-transport. instead, roscovitine could enhance spontaneous [3h]da outflow and inhibit dat-mediated [3h]da reaccumulation into dstr slices. additionally, in a cdk5-independent manner, iso-olomoucine was able to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (ic50 ~37 μm) [1]
IC 50
≥ 1 mm for cdk5
References
[1] price, d. a.,sorkin, a. and zahniser, n.r. cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. molecular pharmacology 76(4), 812-823 (2009).