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CHOLINE THIEOPHYLLINATE

Product Name
CHOLINE THIEOPHYLLINATE
CAS No.
4499-40-5
Chemical Name
CHOLINE THIEOPHYLLINATE
Synonyms
Sabidal;Teovent;filoral;choledyl;cholegyl;Zy-15061;teokolin;Bronchodil;Sabidal SR;theoxylline
CBNumber
CB1441097
Molecular Formula
C12H21N5O3
Formula Weight
283.33
MOL File
4499-40-5.mol
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CHOLINE THIEOPHYLLINATE Property

Melting point:
176-178 °C
storage temp. 
Store at -20°C
solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Safety

HS Code 
2939590000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1484009
Product name
Oxtriphylline
Packaging
500mg
Price
$250
Updated
2024/03/01
Cayman Chemical
Product number
24006
Product name
Oxtriphylline
Purity
≥98%
Packaging
50mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
24006
Product name
Oxtriphylline
Purity
≥98%
Packaging
100mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
24006
Product name
Oxtriphylline
Purity
≥98%
Packaging
500mg
Price
$505
Updated
2024/03/01
TRC
Product number
O867275
Product name
Oxytrimethylline
Packaging
500mg
Price
$160
Updated
2021/12/16
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CHOLINE THIEOPHYLLINATE Chemical Properties,Usage,Production

Originator

Sabidal ,S.R. Zyma, UK ,1983

Uses

Bronchodilator.

Uses

Oxytrimethylline is used in the treatment for chronic asthma.

Manufacturing Process

18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.

brand name

Choledyl(Parke-Davis).

Therapeutic Function

Smooth muscle relaxant

CHOLINE THIEOPHYLLINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHOLINE THIEOPHYLLINATE Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19884
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
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Cayman Chemical Company
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cayman@caymanchem.com
Country
United States
ProdList
6213
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United States Biological
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chemicals@usbio.net
Country
United States
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MedChemExpress
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United States
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HONEST JOY HOLDINGS LIMITED
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sales@honestjoy.cn
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Spectrum Chemicals & Laboratory Products
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View Lastest Price from CHOLINE THIEOPHYLLINATE manufacturers

Qiuxian Baitai New Material Co., LTD
Product
CHOLINE THIEOPHYLLINATE 4499-40-5
Price
US $8.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-26
Dideu Industries Group Limited
Product
CHOLINE THIEOPHYLLINATE 4499-40-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-05-28
Career Henan Chemical Co
Product
CHOLINE THIEOPHYLLINATE 4499-40-5
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

4499-40-5, CHOLINE THIEOPHYLLINATERelated Search:


  • theophyllinecholinate
  • theophyllinesaltofcholine
  • choledyl
  • choledylsa400
  • cholegyl
  • choline,compd.withtheophylline(1:1)
  • cholinetheophyllinesalt
  • cholinophylline
  • ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith3,7-dihydro-1,3-dimethyl-1h
  • 2-hydroxy-N,N,N-trimethylethanaminium 1,3-dimethyl-2-oxo-2,3-dihydro-1H-purin-6-olate
  • Bronchodil
  • choline theophylline
  • Sabidal SR
  • CalcliumTheophylineate
  • theoxylline
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)
  • OXTRIPHYLLINE,USP
  • Sabidal
  • Teovent
  • Zy-15061
  • Oxtriphylline (500 mg)
  • 2-Hydroxy-N,N,N-trimethylethanaminium salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
  • 1,3-dimethyl-2-oxopurin-6-olate,2-hydroxyethyl(trimethyl)azanium
  • OXTRIPHYLLINE
  • (2-hydroxyethyl)trimethylammoniumcompoundwiththeophylline
  • ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith3,7-dihydro-1,3-dimethylp
  • filoral
  • oxtrimethylline
  • -purine-2,6-dione(1:1)
  • soliphylline
  • teofilcolina
  • teokolin
  • RLANKEDHRWMNRO-UHFFFAOYSA-M
  • Oxytrimethylline
  • CHOLINE THIEOPHYLLINATE
  • ChOIiniTheophyllinas
  • CHOLINE THIEOPHYLLINATE USP/EP/BP
  • Oxtriphylline (1484009)
  • Oxtriphylline (Choline theophyllinate)
  • c h oli ne Th e oph ylli na te i s c h oli ne 1,2,3,6-te tra h yd ro-1,3-d i me th yl-2,6-d i oxo-7h -puri n-7-i d e . i t c onta i ns not le ss th a n 41.9% a nd not more th a n 43.6% of c h oli ne , c 5h 15NO2, a nd not le ss th a n 61.7% a nd not more th a n 65.5% of th e oph ylli ne , c 7h 9N4O2, e a c h c a lc ula te d wi th re f e re nc e to th e d ri e d sub sta nc e
  • Cholintheophyllinat
  • 4499-40-5
  • C7H7N4O2C5H14NO
  • API