N-DESMETHYL ZOLMITRIPTAN HCL

Product Name: N-DESMETHYL ZOLMITRIPTAN HCL
CAS No.: 139264-35-0
Chemical Name: N-DESMETHYL ZOLMITRIPTAN HCL
Synonyms: CAS:139264-35-0;Zolmitriptan imp G;ZolMitriptan USP RC A;Desmethyl zolmitriptan;Zolmitriptan Impurity-G;N-Desmethyl Zolmitriptan;Zomitriptan EP impurity G;N-DESMETHYL ZOLMITRIPTAN HCL;ZOLMITRITPAN DESMETHYL ANALOG;ZolMitriptan Related CoMpound A
CBNumber: CB1442160
Molecular Formula: C15H19N3O2
Formula Weight: 273.33
MOL File: 139264-35-0.mol

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N-DESMETHYL ZOLMITRIPTAN HCL Property

Melting point:: 63-66°C
Boiling point:: 577.7±35.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 12.57±0.40(Predicted)
form: Solid
color: Light Yellow to Light Brown
Stability:: Hygroscopic
Major Application: pharmaceutical (small molecule)
InChI: 1S/C15H19N3O2/c1-16-5-4-11-8-17-14-3-2-10(7-13(11)14)6-12-9-20-15(19)18-12/h2-3,7-8,12,16-17H,4-6,9H2,1H3,(H,18,19)/t12-/m0/s1
InChIKey: QGGCHSMZXKNGCK-LBPRGKRZSA-N
SMILES: N1[C@H](COC1=O)Cc2cc3c([nH]cc3CCNC)cc2
CAS DataBase Reference: 139264-35-0

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Safety

HS Code: 2934990002
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28058
Product name: N-desmethyl Zolmitriptan
Packaging: 5mg
Price: $844
Updated: 2024/03/01

TRC

Product number: D296765
Product name: N-DesmethylZolmitriptan
Packaging: 25mg
Price: $1475
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 9049
Product name: N-DesmethylZolmitriptan
Packaging: 5mg
Price: $2040
Updated: 2021/12/16

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N-DESMETHYL ZOLMITRIPTAN HCL Chemical Properties,Usage,Production

Description

N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT_1B and 5-HT_1D agonist zolmitriptan . DZT is an agonist of 5-HT_1B receptors that induces contraction of isolated human cerebral arteries (EC₅₀ = 100 nM).

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.

References

[1] BHARGAV PATEL. Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: a sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study[J]. Biomedical Chromatography, 2015, 30 3: 447-458. DOI: 10.1002/bmc.3568
[2] TORUN NILSSON. Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry[J]. British Journal of Pharmacology, 2009, 128 6: 1133-1140. DOI: 10.1038/sj.bjp.0702773

N-DESMETHYL ZOLMITRIPTAN HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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N-DESMETHYL ZOLMITRIPTAN HCL Suppliers

Canada 4 China 61 France 1 India 8 United Kingdom 1 United States 8 Global 83

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139264-35-0, N-DESMETHYL ZOLMITRIPTAN HCLRelated Search:

Zolmitriptan N-Oxide Zolmitriptan (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one 2-Oxazolidinone, 4-[(2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4-b]indol-6-yl)methyl]-, (4S)- (S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone (S)-3-(2-(dimethylamino)ethyl)-5-((2-oxooxazolidin-4-yl)methyl)-1H-indole-2-carboxylic acid N-Desmethyl Zolmitriptan-d3 (S)-4-(4-Nitrobenzyl)-2-oxazolidinone Sumatriptan Zolmitriptan Zolmitriptan Related Compound D (20 mg) ((S)-Ethyl 3-[2-(dimethylamino)ethyl]-5-[(2-oxooxazolidin-4-yl)methyl]-1H-indole-2-carboxylate) Didesmethyl Zolmitriptan Zolmitriptan Related Compound B (20 mg) ((S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}propan-1-ol) Zolmitriptan Related Compound F N-DESMETHYL ZOLMITRIPTAN HCL ZOLMITRIPTAN-D6 Zolmitriptan Impurity 8 (Mixture of diastereomers)

ZolMitriptan USP RC A

ZolMitriptan Related CoMpound A

CAS:139264-35-0

N-DESMETHYL ZOLMITRIPTAN HCL

4-[[3-[2-(Methylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinon

N-Desmethyl Zolmitriptan

4-[[3-[2-(Methylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinone

Zolmitriptan Related Compound A (20 mg) ((S)-4-({3-[2-(Methylamino)ethyl]-1H-indol-5-yl}methyl)oxazolidin-2-one)

(4S)-4-[[3-[2-(MethylaMino)ethyl]-1H-indol-5-yl]Methyl-2-oxazolidinone

(4S)-4-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one

S)-4-({3-[2-(Methylamino)ethyl]-1H-indol-5-yl}methyl)oxazolidin-2-one

Zolmitriptan Impurity 4(Zolmitriptan USP RC A)

Zolmitriptan EP Impurity G-13C-d3

Zolmitriptan imp G

Zolmitriptan USP Related Compound A

Zolmitriptan EP Impurity G (N-Desmethyl Zolmitriptan)

2-Oxazolidinone, 4-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]methyl]-, (4S)-

Zolmitriptan Impurity-G

Zolmitriptan EP Impurity G/ Zolmitriptan Related Compound A (N-Desmethyl Zolmitriptan)

N-Desmethyl Zolmitriptan HydrochlorideQ: What is N-Desmethyl Zolmitriptan Hydrochloride Q: What is the CAS Number of N-Desmethyl Zolmitriptan Hydrochloride Q: What is the storage condition of N-Desmethyl Zolmitriptan Hydrochloride Q: What are the applications of N-Desmethyl Zolmitriptan Hydrochloride

Zolmitriptan Related Compound A ((S)-4-({3-[2-(Methylamino)ethyl]-1H-indol-5-yl}methyl)oxazolidin-2 (1727020)

Zomitriptan EP impurity G

(S)-4-((3-(2-(methylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (N-Desmethyl Zolmitriptan)

Desmethyl zolmitriptan

Zolmitriptan Impurity 4 Hydrochloride (Zolmitriptan USP Related Compound A Hydrochloride)

N-desmethylzolmitriptan Hydrochloride

ZOLMITRITPAN DESMETHYL ANALOG

Zolmitriptan Impurity: ((S)-4-({3-[2-(Methylamino)ethyl]-1H-indol-5-yl}methyl)oxazolidin-2-one)

Zolmitriptan EP Impurity G (Zolmitriptan USP Related Compound A, N-Desmethyl Zolmitriptan)

139264-35-0

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals