CLORGYLINE HYDROCHLORIDE

ChemicalBook > CAS DataBase List > CLORGYLINE HYDROCHLORIDE

CLORGYLINE HYDROCHLORIDE

Product Name: CLORGYLINE HYDROCHLORIDE
CAS No.: 17780-75-5
Chemical Name: CLORGYLINE HYDROCHLORIDE
Synonyms: Clorgyline HCl;CLORGYLINE HYDROCHLORIDE;Clorgiline (hydrochloride);Clorgyline HCl (M&B 9302, MB9302);N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
CBNumber: CB1445257
Molecular Formula: C13H16Cl3NO
Formula Weight: 308.63
MOL File: 17780-75-5.mol

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CLORGYLINE HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
form: A crystalline solid

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UI0675000
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M3778
Product name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity: ≥97% (GC)
Packaging: 50mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3778
Product name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity: ≥97% (GC)
Packaging: 100mg
Price: $204
Updated: 2024/03/01

Cayman Chemical

Product number: 15925
Product name: Clorgyline (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15925
Product name: Clorgyline (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $56
Updated: 2024/03/01

Sigma-Aldrich

Product number: M3778
Product name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity: ≥97% (GC)
Packaging: 500mg
Price: $696
Updated: 2024/03/01

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CLORGYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (K_is = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ₁ on Jurkat human T lymphocyte cells (IC₅₀ = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.

Uses

Antidepressant;Monoamine oxidase A inhibitor

Uses

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

in MAO-A biochemical assay
to study its effects on the transit of serotonin (5-HT) in the human placenta explants
to study its effects on human prostate cancer cells

Biochem/physiol Actions

MAO-A inhibitor.

References

[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLORGYLINE HYDROCHLORIDE Suppliers

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17780-75-5, CLORGYLINE HYDROCHLORIDERelated Search:

Quartz PROPARGYLAMINE [3-(2-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE [3-(4-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE 3-(4-chlorophenoxy)propan-1-amine AKOS BBS-00007965 Propargylamine hydrochloride N,N-Dimethyl-3-phenoxypropylamine hydrochloride CLORGYLINE 3-phenoxy-1-propanamine 3-(4-CHLOROPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE CLORGYLINE HYDROCHLORIDE 3-(2-chlorophenoxy)propan-1-amine N-methyl-N-(3-phenoxypropyl)amine

CLORGYLINE HYDROCHLORIDE

N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE

3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride

n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride

n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride

N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop

N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride

N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride,Clorgyline

2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-, hydrochloride

3-(2,4-dichlorophenoxy)-n-Methyl-n-prop-2-ynylpropan-1-aMine hydrochloride

Clorgiline (hydrochloride)

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine

Clorgyline HCl

N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride >=97% (GC)

Clorgyline HCl (M&B 9302, MB9302)

17780-75-5

C13H15Cl2NOHCl

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

L to O

Monoamine Oxidase-A

Biochemicals and Reagents

BioChemical