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CLORGYLINE HYDROCHLORIDE

Product Name
CLORGYLINE HYDROCHLORIDE
CAS No.
17780-75-5
Chemical Name
CLORGYLINE HYDROCHLORIDE
Synonyms
Clorgyline HCl;CLORGYLINE HYDROCHLORIDE;Clorgiline (hydrochloride);Clorgyline HCl (M&B 9302, MB9302);N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL;N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
CBNumber
CB1445257
Molecular Formula
C13H16Cl3NO
Formula Weight
308.63
MOL File
17780-75-5.mol
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CLORGYLINE HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
form 
A crystalline solid
color 
White to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
UI0675000
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3778
Product name
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity
≥97% (GC)
Packaging
50mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
M3778
Product name
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity
≥97% (GC)
Packaging
100mg
Price
$204
Updated
2024/03/01
Cayman Chemical
Product number
15925
Product name
Clorgyline (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15925
Product name
Clorgyline (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$56
Updated
2024/03/01
Sigma-Aldrich
Product number
M3778
Product name
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Purity
≥97% (GC)
Packaging
500mg
Price
$696
Updated
2024/03/01
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CLORGYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.

Uses

Antidepressant;Monoamine oxidase A inhibitor

Uses

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

  • in MAO-A biochemical assay
  • to study its effects on the transit of serotonin (5-HT) in the human placenta explants
  • to study its effects on human prostate cancer cells

Biochem/physiol Actions

MAO-A inhibitor.

References

[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLORGYLINE HYDROCHLORIDE Suppliers

China 74 France 1 Germany 1 Switzerland 1 United Kingdom 1 United States 16 USA 1 Global 95

17780-75-5, CLORGYLINE HYDROCHLORIDERelated Search:

Quartz PROPARGYLAMINE [3-(2-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE [3-(4-CHLORO-PHENOXY)-PROPYL]-METHYL-AMINE 3-(4-chlorophenoxy)propan-1-amine AKOS BBS-00007965 Propargylamine hydrochloride N,N-Dimethyl-3-phenoxypropylamine hydrochloride CLORGYLINE 3-phenoxy-1-propanamine 3-(4-CHLOROPHENOXY)PROPAN-1-AMINE HYDROCHLORIDE CLORGYLINE HYDROCHLORIDE 3-(2-chlorophenoxy)propan-1-amine N-methyl-N-(3-phenoxypropyl)amine

  • CLORGYLINE HYDROCHLORIDE
  • N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE
  • 3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride
  • n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride
  • n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
  • N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop
  • N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride
  • N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride,Clorgyline
  • 2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-, hydrochloride
  • 3-(2,4-dichlorophenoxy)-n-Methyl-n-prop-2-ynylpropan-1-aMine hydrochloride
  • Clorgiline (hydrochloride)
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine
  • Clorgyline HCl
  • N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride >=97% (GC)
  • Clorgyline HCl (M&B 9302, MB9302)
  • 17780-75-5
  • C13H15Cl2NOHCl
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • L to O
  • Monoamine Oxidase-A
  • Biochemicals and Reagents
  • BioChemical