2-PYRIDYLTHIOUREA
- Product Name
- 2-PYRIDYLTHIOUREA
- CAS No.
- 14294-11-2
- Chemical Name
- 2-PYRIDYLTHIOUREA
- Synonyms
- 2-PYRIDYLTHIOUREA;AKOS BBS-00007311;N-(2-Pyridyl)thiourea;N-PYRIDIN-2-YLTHIOUREA;1-PYRIDIN-2-YLTHIOUREA;N-2-Pyridinyl-Thiourea;Thiourea,N-2-pyridinyl-;1-(2-PYRIDYL)-2-THIOUREA;N-(2-Pyridyl)thiourea, 98%;1-(Pyridin-2-yl)thiourea 98%
- CBNumber
- CB1445909
- Molecular Formula
- C6H7N3S
- Formula Weight
- 153.2
- MOL File
- 14294-11-2.mol
2-PYRIDYLTHIOUREA Property
- Melting point:
- 148-150°C
- Boiling point:
- 298.7±32.0 °C(Predicted)
- Density
- 1.382±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 12.00±0.70(Predicted)
- color
- White to Light yellow
- BRN
- 117849
- InChI
- InChI=1S/C6H7N3S/c7-6(10)9-5-3-1-2-4-8-5/h1-4H,(H3,7,8,9,10)
- InChIKey
- SLUHLANJIVXTRQ-UHFFFAOYSA-N
- SMILES
- N(C1=NC=CC=C1)C(N)=S
- CAS DataBase Reference
- 14294-11-2(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P2272
- Product name
- (2-Pyridyl)thiourea
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $124
- Updated
- 2025/07/31
- Product number
- P2272
- Product name
- (2-Pyridyl)thiourea
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $421
- Updated
- 2025/07/31
- Product number
- P992135
- Product name
- 2-Pyridylthiourea
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 018986
- Product name
- 1-(2-Pyridyl)-2-thiourea
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- N356
- Product name
- 2-Pyridylthiourea
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
2-PYRIDYLTHIOUREA Chemical Properties,Usage,Production
Uses
2-Pyridylthiourea is an intermediate used to prepare disubstituted thiazoles as potential antibacterial and antiinflammatory agents via condensation of phenacyl bromide with thioureas and thiosemicarbazones. It is also used in the synthesis of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
Synthesis
4921-86-2
14294-11-2
The general procedure for the synthesis of 1-(2-pyridyl)thiourea from 1-benzoyl-3-(2-pyridyl)-2-thiourea was as follows: N-(pyridin-2-ylthiocarbonyl)benzamide (2.3 g, 8.95 mmol) was suspended in a 10% aqueous NaOH solution (10.4 mL, 26 mmol) and stirred for 10 min at room temperature, then heated to reflux to continue the reaction for 10 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with 100 mL of water and subsequently extracted with ethyl acetate (3 × 150 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product 1-(2-pyridyl)thiourea (1.2 g). Mass spectrometry (electrospray ionization) m/z (M+H) confirmed the product.
References
[1] Synthesis, 1988, # 6, p. 456 - 459
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3706 - 3712
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 2, p. 634 - 639
[4] Journal of the Chemical Society, 1955, p. 803
[5] Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 177 - 182
2-PYRIDYLTHIOUREA Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-PYRIDYLTHIOUREA manufacturers
- Product
- 2-PYRIDYLTHIOUREA 14294-11-2
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04