ChemicalBook > CAS DataBase List > 2-PYRIDYLTHIOUREA

2-PYRIDYLTHIOUREA

Product Name
2-PYRIDYLTHIOUREA
CAS No.
14294-11-2
Chemical Name
2-PYRIDYLTHIOUREA
Synonyms
2-PYRIDYLTHIOUREA;AKOS BBS-00007311;N-(2-Pyridyl)thiourea;N-PYRIDIN-2-YLTHIOUREA;1-PYRIDIN-2-YLTHIOUREA;N-2-Pyridinyl-Thiourea;Thiourea,N-2-pyridinyl-;1-(2-PYRIDYL)-2-THIOUREA;N-(2-Pyridyl)thiourea, 98%;1-(Pyridin-2-yl)thiourea 98%
CBNumber
CB1445909
Molecular Formula
C6H7N3S
Formula Weight
153.2
MOL File
14294-11-2.mol
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2-PYRIDYLTHIOUREA Property

Melting point:
148-150°C
Boiling point:
298.7±32.0 °C(Predicted)
Density 
1.382±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
12.00±0.70(Predicted)
color 
White to Light yellow
BRN 
117849
InChI
InChI=1S/C6H7N3S/c7-6(10)9-5-3-1-2-4-8-5/h1-4H,(H3,7,8,9,10)
InChIKey
SLUHLANJIVXTRQ-UHFFFAOYSA-N
SMILES
N(C1=NC=CC=C1)C(N)=S
CAS DataBase Reference
14294-11-2(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
RIDADR 
2811
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2272
Product name
(2-Pyridyl)thiourea
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$124
Updated
2025/07/31
TCI Chemical
Product number
P2272
Product name
(2-Pyridyl)thiourea
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$421
Updated
2025/07/31
TRC
Product number
P992135
Product name
2-Pyridylthiourea
Packaging
1g
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0016674
Product name
2-PYRIDYLTHIOUREA
Purity
95.00%
Packaging
1G
Price
$133.35
Updated
2021/12/16
Matrix Scientific
Product number
056823
Product name
1-(2-Pyridyl)-2-thiourea
Purity
97%
Packaging
5g
Price
$52
Updated
2021/12/16
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2-PYRIDYLTHIOUREA Chemical Properties,Usage,Production

Uses

2-Pyridylthiourea is an intermediate used to prepare disubstituted thiazoles as potential antibacterial and antiinflammatory agents via condensation of phenacyl bromide with thioureas and thiosemicarbazones. It is also used in the synthesis of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.

Synthesis

4921-86-2

14294-11-2

The general procedure for the synthesis of 1-(2-pyridyl)thiourea from 1-benzoyl-3-(2-pyridyl)-2-thiourea was as follows: N-(pyridin-2-ylthiocarbonyl)benzamide (2.3 g, 8.95 mmol) was suspended in a 10% aqueous NaOH solution (10.4 mL, 26 mmol) and stirred for 10 min at room temperature, then heated to reflux to continue the reaction for 10 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with 100 mL of water and subsequently extracted with ethyl acetate (3 × 150 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product 1-(2-pyridyl)thiourea (1.2 g). Mass spectrometry (electrospray ionization) m/z (M+H) confirmed the product.

References

[1] Synthesis, 1988, # 6, p. 456 - 459
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3706 - 3712
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 2, p. 634 - 639
[4] Journal of the Chemical Society, 1955, p. 803
[5] Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 177 - 182

2-PYRIDYLTHIOUREA Preparation Products And Raw materials

Raw materials

Preparation Products

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China 104 France 1 Germany 3 India 3 Japan 1 Ukraine 1 United Kingdom 6 United States 18 Global 137
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View Lastest Price from 2-PYRIDYLTHIOUREA manufacturers

Career Henan Chemical Co
Product
2-PYRIDYLTHIOUREA 14294-11-2
Price
US $500.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-04

14294-11-2, 2-PYRIDYLTHIOUREARelated Search:

2-PYRIDYLTHIOUREA 1-PHENYL-3-(2-PYRIDYL)-2-THIOUREA N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate 3-PYRIDYLTHIOUREA, 98+%,3-PYRIDYLTHIOUREA 4-PYRIDYLTHIOUREA 1-BENZOYL-3-(2-PYRIDYL)-2-THIOUREA 1H-IMIDAZO[4,5-B]PYRIDINE-2-THIOL (6-METHYL-PYRIDIN-2-YL)-THIOUREA METHYL 3-([(2-PYRIDINYLAMINO)CARBOTHIOYL]AMINO)-2-THIOPHENECARBOXYLATE TIMTEC-BB SBB000741 N-ALLYL-N'-PYRIDIN-2-YLTHIOUREA AURORA KA-6689 N-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]THIOUREA N-(((3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYL))AMINO)THIOXOMETHYL)BENZAMIDE 1-(4-BROMOPHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIDO[2,3-D]PYRIMIDIN-4-ONE BUTTPARK 78\40-86 BUTTPARK 78\40-87 BUTTPARK 77\40-81

  • AKOS BBS-00007311
  • 1-(2-PYRIDYL)-2-THIOUREA
  • 1-PYRIDIN-2-YLTHIOUREA
  • 2-PYRIDYLTHIOUREA
  • N-PYRIDIN-2-YLTHIOUREA
  • N-(2-Pyridyl)thiourea, 98%
  • Thiourea,N-2-pyridinyl-
  • N-2-Pyridinyl-Thiourea
  • 1-(Pyridin-2-yl)thiourea 98%
  • N-(2-Pyridyl)thiourea
  • 14294-11-2
  • Pyridines