4-(4-N-BUTYLPHENYL)BENZOIC ACID

Product Name: 4-(4-N-BUTYLPHENYL)BENZOIC ACID
CAS No.: 59662-46-3
Chemical Name: 4-(4-N-BUTYLPHENYL)BENZOIC ACID
Synonyms: RARECHEM AL BO 0889;4-Butylbibenzoic acid;4-Butyl-4''-carboxybiphenyl;4-(4-butylphenyl)benzoic acid;4-(4-N-BUTYLPHENYL)BENZOIC ACID;4'-Butylbiphenyl-4-carboxylic acid;4-BUTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-Butylbiphenyl-4-carboxylic acid;4-N-BUTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid
CBNumber: CB1446643
Molecular Formula: C17H18O2
Formula Weight: 254.32
MOL File: 59662-46-3.mol

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4-(4-N-BUTYLPHENYL)BENZOIC ACID Property

Boiling point:: 413.5±34.0 °C(Predicted)
Density: 1.091±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
pka: 4.22±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 59662-46-3(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809763
Product name: 4''-Butylbiphenyl-4-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 8880AB
Product name: 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 1g
Price: $91
Updated: 2021/12/16

ChemScene

Product number: CS-W022126
Product name: 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid
Purity: >97.0%
Packaging: 5g
Price: $92
Updated: 2021/12/16

ChemScene

Product number: CS-W022126
Product name: 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid
Purity: >97.0%
Packaging: 10g
Price: $146
Updated: 2021/12/16

AK Scientific

Product number: 8880AB
Product name: 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 5g
Price: $172
Updated: 2021/12/16

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4-(4-N-BUTYLPHENYL)BENZOIC ACID Chemical Properties,Usage,Production

Uses

4''-Butylbiphenyl-4-carboxylic Acid is an intermediate used in the preparation of biphenylcarboxylates used as RARβ2 receptor agonist.

Synthesis

1451206-56-6

59662-46-3

General Method 13: Synthesis of biaryl or aryl-heteroaryl carboxylic acids from 1-bromo-4-butylbenzene and arylboronic or heteroarylboronic acids by Suzuki coupling reaction. This method is specifically applied to the synthesis of 4-n-butylbiphenyl-4'-carboxylic acids. A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol) and NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) mixed solvent was heated to reflux and reacted overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, THF was removed by distillation under reduced pressure.The residue was acidified to pH 3-4 with 2N HCl solution.The resulting mixture was filtered and the filter cake was washed with deionized water and dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%) as white solid. The mass spectrum (ESI) showed m/z 255.0 ([M+H]+).

References

[1] Patent: WO2013/123456, 2013, A1. Location in patent: Paragraph 00269; 00271
[2] Patent: WO2017/84629, 2017, A1. Location in patent: Paragraph 00341
[3] Patent: WO2017/84630, 2017, A1. Location in patent: Paragraph 00444
[4] Patent: US2013/217619, 2013, A1. Location in patent: Page/Page column

4-(4-N-BUTYLPHENYL)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-N-BUTYLPHENYL)BENZOIC ACID Suppliers

China 56 Europe 1 Germany 4 India 2 Japan 1 United Kingdom 5 United States 8 Global 77

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View Lastest Price from 4-(4-N-BUTYLPHENYL)BENZOIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-(4-n-butylphenyl)benzoic acid 59662-46-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

LY Global chemicals co.,ltd .

Product: 4-(4-N-BUTYLPHENYL)BENZOIC ACID 59662-46-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98.0%
Supply Ability: 1000kg
Release date: 2023-04-05

Career Henan Chemical Co

Product: 4-(4-N-BUTYLPHENYL)BENZOIC ACID 59662-46-3
Price: US $3.00/KG
Min. Order: 3KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-08-26

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RARECHEM AL BO 0889

4-BUTYL-4'-BIPHENYLCARBOXYLIC ACID

4-N-BUTYLBIPHENYL-4'-CARBOXYLIC ACID

4-(4-N-BUTYLPHENYL)BENZOIC ACID

4-Butyl-4''-carboxybiphenyl

[1,1'-Biphenyl]-4-carboxylicacid, 4'-butyl-

4-(4-N-BUTYLPHENYL)BENZOIC ACID ISO 9001：2015 REACH

4-(4-butylphenyl)benzoic acid

4'-Butylbiphenyl-4-carboxylic acid

4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid

4-Butylbibenzoic acid

4'-Butylbiphenyl-4-carboxylic acid

59662-46-3

Biphenyl & Diphenyl ether