4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

Product Name: 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
CAS No.: 59662-49-6
Chemical Name: 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
Synonyms: 8BCA;AC 55649;AC55649,AC 55649;RARECHEM AL BO 1323;4-(4-Octylphenyl)-benzoic acid;4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID;4'-Octyl[1,1'-biphenyl]-4-carboxylic acid
CBNumber: CB4462046
Molecular Formula: C21H26O2
Formula Weight: 310.43
MOL File: 59662-49-6.mol

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Property

Melting point:: 148-152 °C(Solv: dichloromethane (75-09-2))
Boiling point:: 462.0±34.0 °C(Predicted)
Density: 1.037±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: >7mg/mL
form: solid
pka: 4.23±0.10(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H413May cause long lasting harmful effects to aquatic life

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S945579
Product name: 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID
Purity: Aldrich
Packaging: 25mg
Price: $179
Updated: 2024/03/01

Tocris

Product number: 2436
Product name: AC55649
Purity: ≥99%(HPLC)
Packaging: 50
Price: $593
Updated: 2021/12/16

TRC

Product number: A192203
Product name: AC55649
Packaging: 25mg
Price: $370
Updated: 2021/12/16

Usbiological

Product number: 254514
Product name: AC 55649
Packaging: 10mg
Price: $380
Updated: 2021/12/16

ApexBio Technology

Product number: B7052
Product name: AC55649
Packaging: 10mg
Price: $219
Updated: 2021/12/16

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).

Definition

ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.

Biological Activity

Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Biochem/physiol Actions

AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Suppliers

China 44 Germany 5 Japan 1 Switzerland 1 United Kingdom 2 United States 9 USA 1 Global 63

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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Aikon International Limited

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59662-49-6, 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACIDRelated Search:

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID 4-N-HEPTYLBIPHENYL 4-(4-ETHYLPHENYL)BENZOIC ACID 4-(4-n-Pentylphenyl)benzoic acid 4-N-HEXYLBIPHENYL-4'-CARBOXYLIC ACID 4'-Methylbiphenyl-4-carbaldehyde 4-Hexylbiphenyl 4-(4-N-BUTYLPHENYL)BENZOIC ACID 4-Biphenylcarboxylic acid 4-(4-N-PROPYLPHENYL)BENZOIC ACID 4-N-OCTYLBIPHENYL 4-(4'-N-HEPTYLPHENYL)BENZOIC ACID 4-(4-N-BUTYLPHENYL)BENZALDEHYDE 4-(4-N-PROPYLPHENYL)BENZALDEHYDE 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE 4-methyl-4'-pentyl-1,1'-biphenyl (4'-METHYLBIPHENYL-4-YL)-METHANOL

RARECHEM AL BO 1323

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID

4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID

4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID

4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID

8BCA

AC 55649

4-(4-Octylphenyl)-benzoic acid

4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid

[1,1'-Biphenyl]-4-carboxylic acid, 4'-octyl-

AC55649,AC 55649

4'-Octyl[1,1'-biphenyl]-4-carboxylic acid

59662-49-6

Biphenyl & Diphenyl ether