ChemicalBook > CAS DataBase List > 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

Product Name
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
CAS No.
59662-49-6
Chemical Name
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
Synonyms
8BCA;AC 55649;AC55649,AC 55649;RARECHEM AL BO 1323;4-(4-Octylphenyl)-benzoic acid;4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID;4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
CBNumber
CB4462046
Molecular Formula
C21H26O2
Formula Weight
310.43
MOL File
59662-49-6.mol
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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Property

Melting point:
148-152 °C(Solv: dichloromethane (75-09-2))
Boiling point:
462.0±34.0 °C(Predicted)
Density 
1.037±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: >7mg/mL
form 
solid
pka
4.23±0.10(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S945579
Product name
4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID
Purity
Aldrich
Packaging
25mg
Price
$179
Updated
2024/03/01
Tocris
Product number
2436
Product name
AC55649
Purity
≥99%(HPLC)
Packaging
50
Price
$593
Updated
2021/12/16
TRC
Product number
A192203
Product name
AC55649
Packaging
25mg
Price
$370
Updated
2021/12/16
Usbiological
Product number
254514
Product name
AC 55649
Packaging
10mg
Price
$380
Updated
2021/12/16
ApexBio Technology
Product number
B7052
Product name
AC55649
Packaging
10mg
Price
$219
Updated
2021/12/16
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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).

Definition

ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.

Biological Activity

Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Biochem/physiol Actions

AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Suppliers

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59662-49-6, 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACIDRelated Search:

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID 4-N-HEPTYLBIPHENYL 4-(4-ETHYLPHENYL)BENZOIC ACID 4-(4-n-Pentylphenyl)benzoic acid 4-N-HEXYLBIPHENYL-4'-CARBOXYLIC ACID 4'-Methylbiphenyl-4-carbaldehyde 4-Hexylbiphenyl 4-(4-N-BUTYLPHENYL)BENZOIC ACID 4-Biphenylcarboxylic acid 4-(4-N-PROPYLPHENYL)BENZOIC ACID 4-N-OCTYLBIPHENYL 4-(4'-N-HEPTYLPHENYL)BENZOIC ACID 4-(4-N-BUTYLPHENYL)BENZALDEHYDE 4-(4-N-PROPYLPHENYL)BENZALDEHYDE 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE 4-methyl-4'-pentyl-1,1'-biphenyl (4'-METHYLBIPHENYL-4-YL)-METHANOL

  • RARECHEM AL BO 1323
  • 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
  • 4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID
  • 4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
  • 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID
  • 4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID
  • 8BCA
  • AC 55649
  • 4-(4-Octylphenyl)-benzoic acid
  • 4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid
  • [1,1'-Biphenyl]-4-carboxylic acid, 4'-octyl-
  • AC55649,AC 55649
  • 4'-Octyl[1,1'-biphenyl]-4-carboxylic acid
  • 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
  • 59662-49-6
  • Biphenyl & Diphenyl ether