TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE

Product Name: TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
CAS No.: 156866-52-3
Chemical Name: TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
Synonyms: 4-[(Boc-amino)methyl]benzaldehyde;N-Boc-4-(Aminomethyl)benzaldehyde;tert-butyl 4-formylbenzylcarbamate;TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE;4-(N-TERTBUTOXYAMINOMETHYL)BENZALDEHYDE;4-(Aminomethyl)benzaldehyde, N-BOC protected;Tert-butylN-[(4-formylphenyl)methyl]carbamate;(4-formyl-benzyl)-carbamic acid t-butyl ester;(4-Formylbenzyl)carbamic acid tert-butyl ester;tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Bu
CBNumber: CB1450169
Molecular Formula: C13H17NO3
Formula Weight: 235.28
MOL File: 156866-52-3.mol

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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Property

Melting point:: 83 °C
Boiling point:: 389.0±25.0 °C(Predicted)
Density: 1.108±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline powder
pka: 11.92±0.46(Predicted)
color: Pale yellow
CAS DataBase Reference: 156866-52-3

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-51
Safety Statements: 22-26-36/37/39
Hazard Note: Harmful
HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B129565
Product name: tert-Butyl4-Formylbenzylcarbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139436
Product name: tert-Butyl 4-formylbenzylcarbamate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0024642
Product name: 4-(AMINOMETHYL)BENZALDEHYDE, N-BOC PROTECTED
Purity: 95.00%
Packaging: 250MG
Price: $676.46
Updated: 2021/12/16

Matrix Scientific

Product number: 074750
Product name: tert-Butyl N-(4-formylbenzyl)carbamate
Purity: 95+%
Packaging: 10g
Price: $711
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0024642
Product name: 4-(AMINOMETHYL)BENZALDEHYDE, N-BOC PROTECTED
Purity: 95.00%
Packaging: 1G
Price: $875.84
Updated: 2021/12/16

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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Chemical Properties,Usage,Production

Synthesis

123986-64-1

156866-52-3

General procedure for the synthesis of tert-butyl 4-formylbenzylcarbamate from tert-butyl 4-(hydroxymethyl)benzylcarbamate: tert-butyl 4-(hydroxymethyl)benzylcarbamate (2.20 g, 9.2 mmol) was dissolved in dichloromethane (DCM, 100 ml), and manganese dioxide (MnO2, 8.18 g, 92 mmol, 10 equiv) was added. The resulting suspension was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to afford tert-butyl 4-formylbenzylcarbamate as a white solid (2.18 g, 9.2 mmol, 100% yield). Thin layer chromatography (TLC) analysis showed Rf = 0.62 (Expander: DCM/ethyl acetate, 9:1). Infrared spectroscopy (IR) showed characteristic absorption peaks. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ = 10.0 (s, 1H, CHO), 7.85 (d, J = 8.1 Hz, 2H, ArCH adjacent to CHO), 7.45 (d, J = 8.1 Hz, 2H, ArCH adjacent to CH2NHBoc), 4.99 (bs. 1H, NHBoc), 4.40 (d, J = 5.7 Hz, 2H, CH2NHBoc), 1.47 (s, 9H, C(CH3)3). Nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) δ = 191.9 (CHO), 155.9 (CO), 145.9 (ArCCH2NHBoc), 135.5 (ArCCHO), 130.1 (ArCH adjacent to CHO), 127.6 (ArCH adjacent to CH2NHBoc), 85.1 (C(CH3)3), 44.3 (CH2NHBoc), 28.3 (C(CH3)3). High-resolution mass spectrometry (HRMS, ESI+) showed an m/z of 258.1101 (calculated value: C13H19NO3Na [M+Na]+, 258.1101; measured value: 258.1094). The NMR data are consistent with literature reports.

References

[1] Patent: WO2012/95628, 2012, A1. Location in patent: Page/Page column 18-19
[2] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 148
[3] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 53
[4] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[5] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Suppliers

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View Lastest Price from TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE 156866-52-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

156866-52-3, TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATERelated Search:

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE tert-butyl n-(3-formylbenzyl)carbamate 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID 2-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER [4-(2-P-TOLYL-ACETYL)-BENZYL]-CARBAMIC ACID TERT-BUTYL ESTER (4-PHENYLACETYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-2-YL)BENZOIC ACID 4-(T-BOC-AMINOMETHYL)-3-CHLOROBENZOIC ACID (4-[2-(4-CHLORO-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-[2-(4-METHOXY-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(BOC-AMIDINO)-BENZOIC ACID (4-[2-(4-FLUORO-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER AKOS BBS-00002797 FMOC-LYS-6-N-[4-BOC-AMINOMETHYL-4-(1,2:3,4 DIISOPROPYLIDEN-6-MERCAPTO-ALPHA-D-GALACTOSYL) BENZOYL-AMINO]-OH RARECHEM AL BO 1195

4-(N-TERTBUTOXYAMINOMETHYL)BENZALDEHYDE

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE

4-(Aminomethyl)benzaldehyde, N-BOC protected

Tert-butylN-[(4-formylphenyl)methyl]carbamate

tert-butyl 4-formylbenzylcarbamate

tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Butoxycarbonyl)amino]methyl}benzaldehyde

CarbaMic acid, [(4-forMylphenyl)Methyl]-, 1,1-diMethylethyl ester

(4-Formylbenzyl)carbamic acid tert-butyl ester

tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Bu

N-Boc-4-(Aminomethyl)benzaldehyde

4-[(Boc-amino)methyl]benzaldehyde

(4-formyl-benzyl)-carbamic acid t-butyl ester

Carbamic acid, N-[(4-formylphenyl)methyl]-, 1,1-dimethylethyl ester

156866-52-3