2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

Product Name: 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID
CAS No.: 170097-67-3
Chemical Name: 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID
Synonyms: Lifitegrast Impurity 45;N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDRO;N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic;N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid;N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID;2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Car...;3,4-DIHYDRO-1H-ISOQUINOLINE-2,6-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONIC ACID;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID
CBNumber: CB6238171
Molecular Formula: C15H19NO4
Formula Weight: 277.32
MOL File: 170097-67-3.mol

More

Less

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Property

Boiling point:: 429.3±45.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.33±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Safety

HS Code: 2933992000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B667530
Product name: N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylicAcid
Packaging: 5mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B667530
Product name: N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylicAcid
Packaging: 250mg
Price: $275
Updated: 2021/12/16

Ark Pharm

Product number: P000272952
Product name: 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
Purity: 97%
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Ark Pharm

Product number: P000272952
Product name: 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-7D
Product name: N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
Packaging: 250mg
Price: $231
Updated: 2021/12/16

More

Less

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylic Acid is the starting material used to prepare benzazole derivatives as β-secretase inhibitors useful in treatment and prevention of diseases.

Synthesis

170097-66-2

170097-67-3

Step 2: Synthesis of 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; To a mixture of methanol/tetrahydrofuran (1:1, 6 mL) of the crude urethane obtained from Step 1 was added 1N sodium hydroxide solution (1.97 mL, 1.97 mmol). The reaction mixture was heated to 70 °C and maintained for 1 hour. After the reaction was completed, the mixture was cooled and methanol was removed by rotary evaporator. The remaining aqueous solution was acidified to pH 4 with 1 N hydrochloric acid.The resulting precipitate was collected by vacuum filtration and dried to give the target product (0.34 g, 93% yield), which could be used in subsequent reactions without further purification. Mass spectrum (electrospray positive ion mode) m/e 222.0 [M-tBu]+.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 21, p. 5167 - 5182
[2] Patent: WO2009/49154, 2009, A1. Location in patent: Page/Page column 40
[3] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0596
[4] European Journal of Medicinal Chemistry, 2019, p. 317 - 333
[5] Patent: WO2006/114313, 2006, A1. Location in patent: Page/Page column 159

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID Suppliers

China 81 Germany 1 India 2 United Kingdom 2 United States 19 Global 105

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

ITIC MEDCHEM(SUZHOU) CO.,LTD.

Tel: 0512-68323967 18015559028
Fax: +86-512-69200360
Email: sales@iticmedchem.com
Country: China
ProdList: 506
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

More

Less

View Lastest Price from 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid 170097-67-3
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg,10kg,100kg
Release date: 2020-01-09

170097-67-3, 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACIDRelated Search:

5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 8-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,(3S)-2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID N-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 3-(2-AMINOETHYL)BENZOIC ACID 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE 1,2,3,4-TETRAHYDROISOQUINOLINE 5,6,7,8-TETRAHYDROISOQUINOLINE

3,4-DIHYDRO-1H-ISOQUINOLINE-2,6-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONIC ACID

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic

2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid

2,6(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) ester

N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDRO

N-BOC-6-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE

2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid

2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Car...

Lifitegrast Impurity 45

170097-67-3

pharmacetical