TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE

Product Name: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE
CAS No.: 497068-73-2
Chemical Name: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE
Synonyms: TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE;1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
CBNumber: CB3188525
Molecular Formula: C14H19NO3
Formula Weight: 249.31
MOL File: 497068-73-2.mol

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0379645
Product name: TERT-BUTYL-5-HYDROXY-3,4-DIHYDROQUINOLINE-1-(2H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $500.93
Updated: 2021/12/16

Chemenu

Product number: CM122965
Product name: tert-butyl5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
Purity: 95%
Packaging: 5g
Price: $935
Updated: 2021/12/16

Alichem

Product number: 497068732
Product name: tert-Butyl5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
Packaging: 5g
Price: $1074.06
Updated: 2021/12/16

Chemenu

Product number: CM122965
Product name: tert-butyl5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
Purity: 95%
Packaging: 10g
Price: $1496
Updated: 2021/12/16

Alichem

Product number: 497068732
Product name: tert-Butyl5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
Packaging: 10g
Price: $1700.84
Updated: 2021/12/16

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

24424-99-5

61468-43-7

497068-73-2

GENERAL STEPS: Example 9 Synthesis of (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1-methyl-1,2,3,4-tetrahydro-quinolin-5-yloxy)-propyl]-amine. a) Preparation of tert-butyl 5-hydroxy-3,4-dihydro-2H-quinoline-1-carboxylate: to a stirred 5-hydroxytetrahydroquinoline ( 0.86 g, 5.34 mmol) to a solution of dioxane (25 mL) was added di-tert-butyl dicarbonate (1.16 g, 5.34 mmol). The reaction mixture was stirred at room temperature for 24 hours and then concentrated under vacuum to give an oily product. The crude product was diluted with ether and washed with water. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated to give a thick oily product. Recrystallization by dichloromethane-hexane mixed solvent resulted in 1.25 g of yellow crystal product in 94% yield.

References

[1] Patent: WO2005/23188, 2005, A2. Location in patent: Page/Page column 34
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3415 - 3418

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE Suppliers

China 12 United States 1 Global 13

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795 18030648795
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Aikon International Limited

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SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
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Cool Pharm, Ltd

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Chengdu Forest Science and Technology Development Co,. Ltd

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Abosyn

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Hangzhou Bingochem Co., Ltd.

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Baoji Didu Pharmaceutical and Chemical Co., Ltd

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Shanxi Tihondan Pharmaceutical Technology Co., Ltd

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497068-73-2, TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATERelated Search:

tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 8-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER (3-HYDROXY-PHENYL)-CARBAMIC ACID ISOPROPYL ESTER TERT-BUTYL 5,7-DIMETHOXY-4-OXO-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE N-BOC-3-AMINOPHENOL

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE

1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester

497068-73-2