6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 893566-74-0
Chemical Name: 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: N-BOC-6-bromo-3,4-dihydroisoquinoline;2-Boc-6-bromo-3,4-dihydro-1H-isoquinoline;2-Boc-6-bromo-1,2,3,4-tetrahydroisoquinoline;tert-Butyl 6-bromo-3,4-dihydroisoquinoline-2(1H);tert-butyl 6-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylate;6-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline;tert-butyl 6-broMo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2(1H)-Isoquinolinecarboxylic acid, 6-bromo-3,4-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB41517747
Molecular Formula: C14H18BrNO2
Formula Weight: 312.2
MOL File: 893566-74-0.mol

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6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 374.2±42.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.56±0.20(Predicted)
Appearance: Colorless to light yellow Solid-Liquid Mixture
InChI: InChI=1S/C14H18BrNO2/c1-14(2,3)18-13(17)16-7-6-10-8-12(15)5-4-11(10)9-16/h4-5,8H,6-7,9H2,1-3H3
InChIKey: SZIPGDGOBMFCEH-UHFFFAOYSA-N
SMILES: C1C2=C(C=C(Br)C=C2)CCN1C(OC(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000366839
Product name: tert-Butyl 6-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 97%
Packaging: 1g
Price: $57
Updated: 2021/12/16

Ark Pharm

Product number: P000366839
Product name: tert-Butyl 6-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 97%
Packaging: 5g
Price: $184
Updated: 2021/12/16

Ark Pharm

Product number: P000366839
Product name: tert-Butyl 6-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 97%
Packaging: 250mg
Price: $28
Updated: 2021/12/16

AK Scientific

Product number: 4761AC
Product name: tert-Butyl6-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 5g
Price: $358
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0351165
Product name: TERT-BUTYL-6-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $497.7
Updated: 2021/12/16

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6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

226942-29-6

24424-99-5

893566-74-0

Di-tert-butyl dicarbonate (3.52 g, 16.14 mmol) was slowly added to a solution of 6-bromo-1,2,3,4-tetrahydroisoquinoline (3.26 g, 15.37 mmol) in tetrahydrofuran (45 mL) at room temperature. The reaction mixture was stirred continuously for 15 h at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using solvent gradient elution (0→8% ethyl acetate/hexane) to afford the target compound tert-butyl 6-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (5.05 g, 16.18 mmol, quantitative yield) as a colorless oil.1H NMR (300 MHz, CDCl3) δ: 1.49 (9H, s) ), 2.80 (2H, t, J = 5.9 Hz), 3.62 (2H, t, J = 5.9 Hz), 4.51 (2H, s), 6.97 (1H, d, J = 8.7 Hz), 7.28-7.32 (2H, m).

References

[1] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0594
[2] ChemMedChem, 2018, vol. 13, # 14, p. 1405 - 1413
[3] Patent: WO2013/80222, 2013, A1. Location in patent: Page/Page column 40
[4] Patent: WO2017/184662, 2017, A1. Location in patent: Page/Page column 58
[5] Patent: WO2017/68412, 2017, A1. Location in patent: Page/Page column 274

6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 85 Germany 1 India 2 United States 8 Global 96

PharmaBlock Sciences (Nanjing),Inc.

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View Lastest Price from 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 893566-74-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 200kg
Release date: 2020-01-12

893566-74-0, 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 8-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE TERT-BUTYL 5-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE 5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 3,4-DIHYDROISOQUINOLINE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER (4-BROMO-BENZYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER 6-bromo-1,2,3,4-tetrahydroisoquinoline 2-BOC-6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID

6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

2-Boc-6-bromo-3,4-dihydro-1H-isoquinoline

tert-butyl 6-broMo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

2-Boc-6-bromo-1,2,3,4-tetrahydroisoquinoline

N-BOC-6-bromo-3,4-dihydroisoquinoline

tert-Butyl 6-bromo-3,4-dihydroisoquinoline-2(1H)

6-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline

2(1H)-Isoquinolinecarboxylic acid, 6-bromo-3,4-dihydro-, 1,1-dimethylethyl ester

tert-butyl 6-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylate

893566-74-0

CHIRAL CHEMICALS