3-BROMO-PYRAZOLO[1,5-A]PYRIDINE

Product Name: 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
CAS No.: 5910-12-3
Chemical Name: 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
Synonyms: 3-broMoH-pyrazolo[1,5-a]pyridine;3-Brompyrazolo[1,5-a]pyridin;3-BROMO-PYRAZOLO[1,5-A]PYRIDINE;3-bromopyrazolo[1,5-a]pyridine(SALTDATA: FREE)
CBNumber: CB1451252
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: 5910-12-3.mol

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3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Property

Melting point:: 55 °C(Solv: ligroine (8032-32-4))
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.56±0.30(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C7H5BrN2/c8-6-5-9-10-4-2-1-3-7(6)10/h1-5H
InChIKey: NMPZEHJXHWTZNI-UHFFFAOYSA-N
SMILES: C12=C(Br)C=NN1C=CC=C2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B687033
Product name: 3-Bromo-pyrazolo[1,5-a]pyridine
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51515
Product name: 3-Bromo-pyrazolo[1,5-a]pyridine
Packaging: 25mg
Price: $74.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51515
Product name: 3-Bromo-pyrazolo[1,5-a]pyridine
Packaging: 50mg
Price: $149
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51515
Product name: 3-Bromo-pyrazolo[1,5-a]pyridine
Packaging: 100mg
Price: $238
Updated: 2021/12/16

Apolloscientific

Product number: OR346595
Product name: 3-Bromo-pyrazolo[1,5-a]pyridine
Purity: 95+%
Packaging: 1g
Price: $253
Updated: 2021/12/16

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3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Chemical Properties,Usage,Production

Uses

3-Bromopyrazolo[1,5-a]pyridine is used as a pharmaceutical intermediate compound for the preparation of Hpk1 antagonists.

Synthesis

16205-46-2

5910-12-3

The general procedure for the synthesis of 3-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid from pyrazolo[1,5-a]pyridine was as follows: N-bromosuccinimide (3.06 g, 17.22 mmol) and sodium bicarbonate (4.34 g, 51.66 mmol) were sequentially added to a N,N-dimethylformamide (40 mL) solution of pyrazolo[1,5-a]pyridine-3-carboxylic acid (2.81 g, 17.22 mmol) in a solution of N,N-dimethylformamide (40 mL). The reaction mixture was stirred at room temperature for 4 h and then poured into water (100 mL). The resulting suspension was extracted twice with ethyl acetate and the organic layers were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate = 8:2) to afford the target product 3-bromopyrazolo[1,5-a]pyridine (2.58 g, 76% yield). Mass spectrum (LRMS) showed m/z: 197 ([M+1]+). 1H-NMR (250 MHz, CDCl3) δ: 6.8 (t, 1H), 7.2 (t, 1H), 7.5 (d, 1H), 7.9 (s, 1H), 8.4 (d, 1H).

References

[1] Patent: WO2011/101161, 2011, A1. Location in patent: Page/Page column 99

3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Suppliers

China 96 France 1 Germany 2 India 3 Switzerland 1 United Kingdom 2 United States 11 Global 116

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View Lastest Price from 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE manufacturers

Career Henan Chemical Co

Product: 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE 5910-12-3
Price: US $3.00/ASSAYS
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

5910-12-3, 3-BROMO-PYRAZOLO[1,5-A]PYRIDINERelated Search:

3-bromoH-pyrazolo[1,5-a]pyridine-2-carboxylic acid 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Pyrazolo[1,5-a]pyridine 3-BROMO-2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE

3-BROMO-PYRAZOLO[1,5-A]PYRIDINE

3-bromopyrazolo[1,5-a]pyridine(SALTDATA: FREE)

3-broMoH-pyrazolo[1,5-a]pyridine

3-Brompyrazolo[1,5-a]pyridin

5910-12-3

organic buiding block