ChemicalBook > CAS DataBase List > 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE

3-BROMO-PYRAZOLO[1,5-A]PYRIDINE

Product Name
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
CAS No.
5910-12-3
Chemical Name
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
Synonyms
3-broMoH-pyrazolo[1,5-a]pyridine;3-Brompyrazolo[1,5-a]pyridin;3-BROMO-PYRAZOLO[1,5-A]PYRIDINE;3-bromopyrazolo[1,5-a]pyridine(SALTDATA: FREE)
CBNumber
CB1451252
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
5910-12-3.mol
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3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Property

Melting point:
55 °C(Solv: ligroine (8032-32-4))
Density 
1.69±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
0.56±0.30(Predicted)
Appearance
Off-white to gray Solid
InChI
InChI=1S/C7H5BrN2/c8-6-5-9-10-4-2-1-3-7(6)10/h1-5H
InChIKey
NMPZEHJXHWTZNI-UHFFFAOYSA-N
SMILES
C12=C(Br)C=NN1C=CC=C2
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B687033
Product name
3-Bromo-pyrazolo[1,5-a]pyridine
Packaging
50mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
076242
Product name
3-Bromopyrazolo[1,5-a]pyridine
Purity
95+%
Packaging
1g
Price
$639
Updated
2021/12/16
AK Scientific
Product number
W7200
Product name
3-Bromopyrazolo[1,5-a]pyridine
Packaging
5g
Price
$717
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0029068
Product name
3-BROMO-PYRAZOLO-[1,5-A]PYRIDINE
Purity
95.00%
Packaging
250MG
Price
$903.21
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-BY
Product name
3-Bromopyrazolo[1,5-a]pyridine
Purity
95.0%
Packaging
5G
Price
$917
Updated
2021/12/16
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3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Chemical Properties,Usage,Production

Uses

3-Bromopyrazolo[1,5-a]pyridine is used as a pharmaceutical intermediate compound for the preparation of Hpk1 antagonists.

Synthesis

16205-46-2

5910-12-3

The general procedure for the synthesis of 3-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid from pyrazolo[1,5-a]pyridine was as follows: N-bromosuccinimide (3.06 g, 17.22 mmol) and sodium bicarbonate (4.34 g, 51.66 mmol) were sequentially added to a N,N-dimethylformamide (40 mL) solution of pyrazolo[1,5-a]pyridine-3-carboxylic acid (2.81 g, 17.22 mmol) in a solution of N,N-dimethylformamide (40 mL). The reaction mixture was stirred at room temperature for 4 h and then poured into water (100 mL). The resulting suspension was extracted twice with ethyl acetate and the organic layers were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate = 8:2) to afford the target product 3-bromopyrazolo[1,5-a]pyridine (2.58 g, 76% yield). Mass spectrum (LRMS) showed m/z: 197 ([M+1]+). 1H-NMR (250 MHz, CDCl3) δ: 6.8 (t, 1H), 7.2 (t, 1H), 7.5 (d, 1H), 7.9 (s, 1H), 8.4 (d, 1H).

References

[1] Patent: WO2011/101161, 2011, A1. Location in patent: Page/Page column 99

3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE manufacturers

Career Henan Chemical Co
Product
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE 5910-12-3
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

5910-12-3, 3-BROMO-PYRAZOLO[1,5-A]PYRIDINERelated Search:

3-bromoH-pyrazolo[1,5-a]pyridine-2-carboxylic acid 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Pyrazolo[1,5-a]pyridine 3-BROMO-2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE

  • 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
  • 3-bromopyrazolo[1,5-a]pyridine(SALTDATA: FREE)
  • 3-broMoH-pyrazolo[1,5-a]pyridine
  • 3-Brompyrazolo[1,5-a]pyridin
  • 5910-12-3
  • organic buiding block