ChemicalBook > CAS DataBase List > 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE

Product Name
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
CAS No.
175205-09-1
Chemical Name
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
Synonyms
Activator 42;KG-548;KG-548 (KG548);BUTTPARK 1\01-72;Activator 42(R) 0.1 M;Activator 42?;5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra;5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE;5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%;5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
CBNumber
CB1454172
Molecular Formula
C9H4F6N4
Formula Weight
282.15
MOL File
175205-09-1.mol
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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Property

Melting point:
177-180°C
Boiling point:
298.2±50.0 °C(Predicted)
Density 
1.569±0.06 g/cm3(Predicted)
Flash point:
5℃
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble20mg/mL, clear
pka
3.59±0.10(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
175205-09-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Hazard Note 
Irritant
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L031000
Product name
Activator 42®
Purity
0.1 M
Packaging
6X450ML
Price
$558
Updated
2025/07/31
Sigma-Aldrich
Product number
L031100
Product name
KG-548
Purity
70-77 g/L (Activator 42 content, titration)
Packaging
6x450ml
Price
$541
Updated
2025/07/31
Sigma-Aldrich
Product number
L031100
Product name
KG-548
Purity
70-77 g/L (Activator 42 content, titration)
Packaging
10l
Price
$1310
Updated
2025/07/31
Sigma-Aldrich
Product number
L031180
Product name
KG-548
Purity
70-77 g/L (Activator 42 content, titration)
Packaging
6x200ml
Price
$235
Updated
2025/07/31
Sigma-Aldrich
Product number
L031100
Product name
KG-548
Purity
70-77 g/L (Activator 42 content, titration)
Packaging
4x2.5l
Price
$1310
Updated
2025/07/31
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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Chemical Properties,Usage,Production

Uses

KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].

References

[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Suppliers

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175205-09-1, 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLERelated Search:

Trifluoromethanesulfonimide BUTTPARK 44\01-39 BUTTPARK 1\01-79 N'1-(2-CHLOROACETYL)-2-(5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOL-2-YL)PROPANOHYDRAZIDE BUTTPARK 1\01-77 BUTTPARK 1\01-74 BUTTPARK 1\01-73 BUTTPARK 17\01-53 BUTTPARK 1\01-86 BUTTPARK 1\01-78 2-([5-[(2,6-DICHLOROBENZYL)THIO]-4-(3,4-DICHLOROPHENYL)-4H-1,2,4-TRIAZOL-3-YL]METHYL)-5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE BUTTPARK 1\01-81 BUTTPARK 1\01-87

  • BUTTPARK 1\01-72
  • 5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE
  • 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
  • 5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole 97%
  • 5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%
  • 5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole
  • 5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole 97%
  • KG-548
  • 5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
  • 5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra
  • 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAZOLE
  • Activator 42
  • KG-548 (KG548)
  • 2H-Tetrazole, 5-[3,5-bis(trifluoromethyl)phenyl]-
  • Activator 42(R) 0.1 M
  • Activator 42<sup>?</sup>
  • 175205-09-1
  • C8H4F6N4
  • C9H4F6N4