5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
- Product Name
- 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
- CAS No.
- 175205-09-1
- Chemical Name
- 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
- Synonyms
- Activator 42;KG-548;KG-548 (KG548);BUTTPARK 1\01-72;Activator 42(R) 0.1 M;Activator 42?;5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra;5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE;5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%;5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
- CBNumber
- CB1454172
- Molecular Formula
- C9H4F6N4
- Formula Weight
- 282.15
- MOL File
- 175205-09-1.mol
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Property
- Melting point:
- 177-180°C
- Boiling point:
- 298.2±50.0 °C(Predicted)
- Density
- 1.569±0.06 g/cm3(Predicted)
- Flash point:
- 5℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 3.59±0.10(Predicted)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 175205-09-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- Hazard Note
- Irritant
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L031000
- Product name
- Activator 42®
- Purity
- 0.1 M
- Packaging
- 6X450ML
- Price
- $558
- Updated
- 2025/07/31
- Product number
- L031100
- Product name
- KG-548
- Purity
- 70-77 g/L (Activator 42 content, titration)
- Packaging
- 6x450ml
- Price
- $541
- Updated
- 2025/07/31
- Product number
- L031100
- Product name
- KG-548
- Purity
- 70-77 g/L (Activator 42 content, titration)
- Packaging
- 10l
- Price
- $1310
- Updated
- 2025/07/31
- Product number
- L031100
- Product name
- KG-548
- Purity
- 70-77 g/L (Activator 42 content, titration)
- Packaging
- 4x2.5l
- Price
- $1310
- Updated
- 2025/07/31
- Product number
- L031180
- Product name
- KG-548
- Purity
- 70-77 g/L (Activator 42 content, titration)
- Packaging
- 6x200ml
- Price
- $235
- Updated
- 2025/07/31
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Chemical Properties,Usage,Production
Uses
KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].
References
[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75