1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Product Name: 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
CAS No.: 25371-96-4
Chemical Name: 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
Synonyms: TRIM;I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE;1-(2-Trifluoromethylphenyl)imidazole, 98+%;1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%;2-chloro-3-(dodecylamino)naphthalene-1,4-dione;1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE
CBNumber: CB1457890
Molecular Formula: C10H7F3N2
Formula Weight: 212.17
MOL File: 25371-96-4.mol

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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Property

Melting point:: 43 °C
Boiling point:: 75°C 0,02mm
Density: 1.3253 (estimate)
Flash point:: 75°C/0.025mm
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
form: White solid.
pka: 4.96±0.10(Predicted)
color: White
Sensitive: Light Sensitive
BRN: 3955637
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference: 25371-96-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, LIGHT SENSITIVE
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T7313
Product name: 1-[2-(Trifluoromethyl)phenyl]imidazole
Packaging: 100mg
Price: $165
Updated: 2024/03/01

TCI Chemical

Product number: T2982
Product name: 1-[2-(Trifluoromethyl)phenyl]imidazole
Purity: min. 98.0 %
Packaging: 200MG
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: T2982
Product name: 1-[2-(Trifluoromethyl)phenyl]imidazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 81310
Product name: TRIM
Purity: ≥98%
Packaging: 50mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 81310
Product name: TRIM
Purity: ≥98%
Packaging: 100mg
Price: $62
Updated: 2024/03/01

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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemical Properties,Usage,Production

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

Uses

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

Definition

ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Suppliers

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View Lastest Price from 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE manufacturers

Career Henan Chemical Co

Product: 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 25371-96-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

25371-96-4, 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLERelated Search:

U-74389G JZL 184 1-(2-HYDROXY-ETHYL)-PIPERIDINE-4-CARBOXYLIC ACID AMIDE 1-(2-CYANOPHENYL)PIPERAZINE 1-(2-Chloro-6-Methoxyphenyl)ethanone 1-(2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE 1-(2-CARBOXYPHENYL)PYRROLE 1-(2-aMino-4-chlorophenyl)ethanone 1-(2-CHLOROETHYL)-4-CYANOPIPERIDINE HYDROCHLORIDE 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLINE-2-THIONE 1-Phenylimidazole 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 1-(2-TRIFLUOROMETHYLPHENYL)-IMIDAZOLE-2-CARBOXYLIC ACID 1-O-TOLYL-1H-IMIDAZOLE 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE,1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 98% 2-OXO-4-(4-TRIFLUOROMETHYLPHENYL)-IMIDAZOLE-5-CARBOXYLIC ACID 1-(2-TRIFLUOROMETHYLPHENYL)-IMIDAZOLE-2-

I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE

TRIM

1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%

1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%

1-(2-Trifluoromethylphenyl)imidazole, 98+%

2-(1H-Imidazol-1-yl)benzotrifluoride, 1-(1H-Imidazol-1-yl)-2-(trifluoromethyl)benzene

2-chloro-3-(dodecylamino)naphthalene-1,4-dione

1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-

nNOS,eNOS,Inhibitor,TRIM,inhibit,anxiolytic-like effects,NO Synthase,Nitric oxide synthases,iNOS,antidepressant,NOS

25371-96-4

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Nitric Oxide Synthase

L to O

BioChemical

Biochemicals and Reagents

Imidazol&Benzimidazole