ChemicalBook > CAS DataBase List > 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Product Name
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
CAS No.
25371-96-4
Chemical Name
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
Synonyms
TRIM;TRIM, 10 mM in DMSO;I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE;1-(2-Trifluoromethylphenyl)imidazole, 98+%;1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%;2-chloro-3-(dodecylamino)naphthalene-1,4-dione
CBNumber
CB1457890
Molecular Formula
C10H7F3N2
Formula Weight
212.17
MOL File
25371-96-4.mol
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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Property

Melting point:
43 °C
Boiling point:
75°C 0,02mm
Density 
1.3253 (estimate)
Flash point:
75°C/0.025mm
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
form 
White solid.
pka
4.96±0.10(Predicted)
color 
White
biological source
synthetic (organic)
Sensitive 
Light Sensitive
BRN 
3955637
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference
25371-96-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T7313
Product name
1-[2-(Trifluoromethyl)phenyl]imidazole
Packaging
100mg
Price
$165
Updated
2024/03/01
TCI Chemical
Product number
T2982
Product name
1-[2-(Trifluoromethyl)phenyl]imidazole
Purity
min. 98.0 %
Packaging
200MG
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
T2982
Product name
1-[2-(Trifluoromethyl)phenyl]imidazole
Purity
>98.0%(GC)
Packaging
1g
Price
$254
Updated
2024/03/01
Cayman Chemical
Product number
81310
Product name
TRIM
Purity
≥98%
Packaging
50mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
81310
Product name
TRIM
Purity
≥98%
Packaging
100mg
Price
$62
Updated
2024/03/01
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1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemical Properties,Usage,Production

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

Uses

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

Definition

ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE manufacturers

Career Henan Chemical Co
Product
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 25371-96-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

25371-96-4, 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLERelated Search:

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  • I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
  • 1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE
  • 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
  • 1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE
  • TRIM
  • 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%
  • 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%
  • 1-(2-Trifluoromethylphenyl)imidazole, 98+%
  • 2-(1H-Imidazol-1-yl)benzotrifluoride, 1-(1H-Imidazol-1-yl)-2-(trifluoromethyl)benzene
  • 2-chloro-3-(dodecylamino)naphthalene-1,4-dione
  • 1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-
  • nNOS,eNOS,Inhibitor,TRIM,inhibit,anxiolytic-like effects,NO Synthase,Nitric oxide synthases,iNOS,antidepressant,NOS
  • TRIM, 10 mM in DMSO
  • 25371-96-4
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Nitric Oxide Synthase
  • L to O
  • BioChemical
  • Biochemicals and Reagents
  • Imidazol&Benzimidazole