N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

Product Name: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
CAS No.: 249889-64-3
Chemical Name: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms: CS-1473;SB 334867;SB 334867A;Zinc00008794;SB334867 HCl;SB-334867 hydrochloride;SB 334867 hydrochloride NEW;SB 334867A; SB334867; SB 334867;N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)
CBNumber: CB1458943
Molecular Formula: C17H13N5O2
Formula Weight: 319.32
MOL File: 249889-64-3.mol

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Property

Melting point:: >235°C (dec.)
storage temp.: Desiccate at RT
solubility: Dichloromethane (Slightly), DMSO (Slightly)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris

Product number: 1960
Product name: SB334867
Purity: ≥99%(HPLC)
Packaging: 1
Price: $96
Updated: 2021/12/16

Tocris

Product number: 1960
Product name: SB334867
Purity: ≥99%(HPLC)
Packaging: 10
Price: $203
Updated: 2021/12/16

Tocris

Product number: 1960
Product name: SB334867
Purity: ≥99%(HPLC)
Packaging: 50
Price: $852
Updated: 2021/12/16

TRC

Product number: S154655
Product name: SB334867
Packaging: 100mg
Price: $1260
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008815
Product name: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $1381.33
Updated: 2021/12/16

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production

Uses

SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Suppliers

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249889-64-3, N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREARelated Search:

1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride 1,5-NAPHTHYRIDIN-4-AMINE N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

SB 334867

SB 334867 hydrochloride NEW

Zinc00008794

Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)

SB334867 HCl

SB-334867 hydrochloride

CS-1473

SB 334867A

SB 334867A; SB334867; SB 334867

Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, hydrochloride (1:1)

249889-64-3

C17H13N5O2

C17H13N5O2HCl

Orexin receptor