ChemicalBook > CAS DataBase List > N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

Product Name
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
CAS No.
249889-64-3
Chemical Name
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms
CS-1473;SB 334867;SB 334867A;Zinc00008794;SB334867 HCl;SB-334867 hydrochloride;SB 334867 hydrochloride NEW;SB 334867A; SB334867; SB 334867;N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)
CBNumber
CB1458943
Molecular Formula
C17H13N5O2
Formula Weight
319.32
MOL File
249889-64-3.mol
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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Property

Melting point:
>235°C (dec.)
storage temp. 
Desiccate at RT
solubility 
Dichloromethane (Slightly), DMSO (Slightly)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris
Product number
1960
Product name
SB334867
Purity
≥99%(HPLC)
Packaging
1
Price
$96
Updated
2021/12/16
Tocris
Product number
1960
Product name
SB334867
Purity
≥99%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
Tocris
Product number
1960
Product name
SB334867
Purity
≥99%(HPLC)
Packaging
50
Price
$852
Updated
2021/12/16
TRC
Product number
S154655
Product name
SB334867
Packaging
100mg
Price
$1260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008815
Product name
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$1381.33
Updated
2021/12/16
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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production

Uses

SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Suppliers

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249889-64-3, N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREARelated Search:

1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride 1,5-NAPHTHYRIDIN-4-AMINE N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

  • N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
  • SB 334867
  • SB 334867 hydrochloride NEW
  • Zinc00008794
  • Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)
  • SB334867 HCl
  • SB-334867 hydrochloride
  • CS-1473
  • SB 334867A
  • SB 334867A; SB334867; SB 334867
  • Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, hydrochloride (1:1)
  • 249889-64-3
  • C17H13N5O2
  • C17H13N5O2HCl
  • Orexin receptor