(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

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(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Product Name: (Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS No.: 2093243-16-2
Chemical Name: (Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Synonyms: Nintedanib-013-Z;Nidanibu Impurity 8;Nintedanib impurities11;(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;Nintedanib impurity 12/Methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(hydroxyphenylmethylene)-2-oxo-, methyl ester, (3Z)-
CBNumber: CB14656048
Molecular Formula: C17H13NO4
Formula Weight: 295.29
MOL File: 2093243-16-2.mol

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(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Property

Melting point:: >215°C (dec.)
Boiling point:: 536.9±50.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 4.50±1.00(Predicted)
color: Yellow to Dark Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M323629
Product name: (Z)-Methyl3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Packaging: 50mg
Price: $235
Updated: 2021/12/16

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(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties,Usage,Production

Uses

(Z)-Methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is a useful intermediate for the preparation of nintedanib esylate. Nintedanib is a drug for the treatment of idiopathic pulmonary fibrosis.

(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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2093243-16-2, (Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylateRelated Search:

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(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Nintedanib impurity 12/Methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Nintedanib-013-Z

Nidanibu Impurity 8

Nintedanib impurities11

1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(hydroxyphenylmethylene)-2-oxo-, methyl ester, (3Z)-

2093243-16-2