KY-226

Product Name: KY-226
CAS No.: 1621673-53-7
Chemical Name: KY-226
Synonyms: KY-226;4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide;Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-;inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226
CBNumber: CB14668126
Molecular Formula: C27H31NO3S2
Formula Weight: 481.67
MOL File: 1621673-53-7.mol

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KY-226 Property

Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (>25 mg/ml).
pka: 3.91±0.40(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 100mg
Price: $1100
Updated: 2021/12/16

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KY-226 Chemical Properties,Usage,Production

Description

KY-226 (CAS 1621673-53-7)? is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50?= 250 nM) with no activity at PPARγ.1?It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2?It has been suggested that KY-226’s anti-diabetic effects occur?via?enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2?KY-226 has also been shown to protect neurons from cerebral ischemia.3?This effect is mediated by restoration of tight junction proteins?via?activation of the Akt/FoxO1 pathway.4

References

1) Morashita (2017),?Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitor with Non-competitive Actions;?Chem.Pharm.Bull.?65?1144 2) Ito?et al.?(2018),?Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice;?J.Pharmacol.Sci?137?38 3) Sun?et al.?(2018),?Neuroprotective effects of protein tyrosine phosphatase 1B on cerebral ischemia/reperfusion in mice;?Brain Res.?1694?1 4) Sun?et al.?(2019),?KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway on Brain Ischemia;?Neuroscience?399?89

KY-226 Preparation Products And Raw materials

Raw materials

Preparation Products

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KY-226 Suppliers

China 22 United States 6 Global 28

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Email: 3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
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Email: Sales@ATKchemical.com
Country: China
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Chuzhou KeMail Chemical Technology Co., Ltd

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Fax: 0550-5196001
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Country: China
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Zhejiang J&C Biological Technology Co.,Limited

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InvivoChem

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Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
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DC Chemicals

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BOC Sciences

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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1621673-53-7, KY-226Related Search:

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KY-226

Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-

4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide

inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226

1621673-53-7