KY-226

Product Name: KY-226
CAS No.: 1621673-53-7
Chemical Name: KY-226
Synonyms: KY-226;KY-226, 10 mM in DMSO;4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide;Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-;inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226
CBNumber: CB14668126
Molecular Formula: C27H31NO3S2
Formula Weight: 481.67
MOL File: 1621673-53-7.mol

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KY-226 Property

Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (>25 mg/ml).
pka: 3.91±0.40(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0077591
Product name: KY-226
Purity: 98.02%
Packaging: 100mg
Price: $1100
Updated: 2021/12/16

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KY-226 Chemical Properties,Usage,Production

Description

KY-226 (CAS 1621673-53-7)? is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50?= 250 nM) with no activity at PPARγ.1?It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2?It has been suggested that KY-226’s anti-diabetic effects occur?via?enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2?KY-226 has also been shown to protect neurons from cerebral ischemia.3?This effect is mediated by restoration of tight junction proteins?via?activation of the Akt/FoxO1 pathway.4

Uses

KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury[1][2].

in vivo

KY-226 (10-30 mg/kg/day; oral administration; daily; for 4 weeks; male db/db mice) treatment significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain^[1].
KY-226 attenuates plasma glucose elevations in the oral glucose tolerance test. KY-226 also increases pIR and phosphorylated Akt in the liver and femoral muscle^[1].

Animal Model:	Male db/db mice (8-11 weeks old)^[1]
Dosage:	10 mg/kg and 30 mg/kg
Administration:	Oral administration; daily; for 4 weeks
Result:	Significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.

References

[1] KO MORISHITA. Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitors with Non-competitive Actions.[J]. Chemical & pharmaceutical bulletin, 2017, 65 12: 1144-1160. DOI:10.1248/cpb.c17-00635
[2] YUMA ITO . Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice[J]. Journal of pharmacological sciences, 2018, 137 1: Pages 38-46. DOI:10.1016/j.jphs.2018.03.001
[3] MEILING SUN. Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice[J]. Brain Research, 2018, 1694: Pages 1-12. DOI:10.1016/j.brainres.2018.04.029
[4] MEILING SUN Kohji F Yasuharu Shinoda. KY-226 Protects Blood–brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia[J]. Neuroscience, 2019, 399: Pages 89-102. DOI:10.1016/j.neuroscience.2018.12.024

KY-226 Preparation Products And Raw materials

Raw materials

Preparation Products

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KY-226 Suppliers

China 31 United States 6 Global 37

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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KY-226

Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-

4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide

inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226

KY-226, 10 mM in DMSO

1621673-53-7