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KY-226

Product Name
KY-226
CAS No.
1621673-53-7
Chemical Name
KY-226
Synonyms
KY-226;KY-226, 10 mM in DMSO;4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide;Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-;inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226
CBNumber
CB14668126
Molecular Formula
C27H31NO3S2
Formula Weight
481.67
MOL File
1621673-53-7.mol
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KY-226 Property

Density 
1.186±0.06 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (>25 mg/ml).
pka
3.91±0.40(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0077591
Product name
KY-226
Purity
98.02%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0077591
Product name
KY-226
Purity
98.02%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0077591
Product name
KY-226
Purity
98.02%
Packaging
25mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0077591
Product name
KY-226
Purity
98.02%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0077591
Product name
KY-226
Purity
98.02%
Packaging
100mg
Price
$1100
Updated
2021/12/16
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KY-226 Chemical Properties,Usage,Production

Description

KY-226 (CAS 1621673-53-7)? is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50?= 250 nM) with no activity at PPARγ.1?It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2?It has been suggested that KY-226’s anti-diabetic effects occur?via?enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2?KY-226 has also been shown to protect neurons from cerebral ischemia.3?This effect is mediated by restoration of tight junction proteins?via?activation of the Akt/FoxO1 pathway.4

References

1) Morashita (2017),?Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitor with Non-competitive Actions;?Chem.Pharm.Bull.?65?1144 2) Ito?et al.?(2018),?Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice;?J.Pharmacol.Sci?137?38 3) Sun?et al.?(2018),?Neuroprotective effects of protein tyrosine phosphatase 1B on cerebral ischemia/reperfusion in mice;?Brain Res.?1694?1 4) Sun?et al.?(2019),?KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway on Brain Ischemia;?Neuroscience?399?89

KY-226 Preparation Products And Raw materials

Raw materials

Preparation Products

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KY-226 Suppliers

China 26 United States 6 Global 32
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1621673-53-7, KY-226Related Search:

EFAROXAN HYDROCHLORIDE GW9508 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione CHIR-99021

  • KY-226
  • Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-
  • 4-[[([1,1'-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide
  • inhibit,anti-diabetic,leptin,ZO-1,LPS,insulin,phosphorylated,KY-226,Akt,KY226,anti-obesity,PTP1B,Phosphatase,neurons,Inhibitor,KY 226
  • KY-226, 10 mM in DMSO
  • 1621673-53-7