2'-O-(2-Cyanoethyl)adenosine
- Product Name
- 2'-O-(2-Cyanoethyl)adenosine
- CAS No.
- 2226475-42-7
- Chemical Name
- 2'-O-(2-Cyanoethyl)adenosine
- Synonyms
- 2'-O-(2-Azidoethyl)adenosine;2'-O-(2-Cyanoethyl)adenosine
- CBNumber
- CB14672415
- Molecular Formula
- C12H16N8O4
- Formula Weight
- 336.31
- MOL File
- 2226475-42-7.mol
2'-O-(2-Cyanoethyl)adenosine Chemical Properties,Usage,Production
Uses
2’-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2’-O-(2-Azidoethyl)adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
2'-O-(2-Cyanoethyl)adenosine Preparation Products And Raw materials
Raw materials
Preparation Products
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