BROFOXINE

Product Name: BROFOXINE
CAS No.: 21440-97-1
Chemical Name: BROFOXINE
Synonyms: FI-6820;F.I.6820;BROFOXINE;dimethabrone;4,4-Dimethyl-6-bromo-1,3-benzoxazine-2-one;4h-4-dimethyl-6-bromo-3,1-benzoxazine-2-one;6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one;6-Bromo-4,4-dimethyl-4H-3,1-benzoxazin-2(1H)-one;6-bromo-1,4-dihydro-4,4-dimethyl-2h-1-benzoxazin-2-one;1,2-dihydro-6-bromo-4,4-dimethyl-4h-1-benzoxazin-2-one
CBNumber: CB1468032
Molecular Formula: C10H10BrNO2
Formula Weight: 256.1
MOL File: 21440-97-1.mol

More

Less

BROFOXINE Property

storage temp.: 2-8°C
CAS DataBase Reference: 21440-97-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 074123
Product name: 6-Bromo-4,4-dimethyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one
Purity: 95+%
Packaging: 1g
Price: $400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013667
Product name: 6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-2H-3,1-BENZOXAZIN-2-ONE
Purity: 95.00%
Packaging: 1G
Price: $958.65
Updated: 2021/12/16

Matrix Scientific

Product number: 074123
Product name: 6-Bromo-4,4-dimethyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one
Purity: 95+%
Packaging: 5g
Price: $1069
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013667
Product name: 6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-2H-3,1-BENZOXAZIN-2-ONE
Purity: 95.00%
Packaging: 5G
Price: $1739.43
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013667
Product name: 6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-2H-3,1-BENZOXAZIN-2-ONE
Purity: 95.00%
Packaging: 10G
Price: $2453.22
Updated: 2021/12/16

More

Less

BROFOXINE Chemical Properties,Usage,Production

Uses

Antipsychotic.

Synthesis

530-62-1

304853-89-2

21440-97-1

Step 2: Synthesis of 6-bromo-4,4-dimethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; the compound was prepared with reference to U.S. Patent No. 4,522,576 and U.S. Patent No. 6,444,668. to an anhydrous nitrogen-protected 2-(2-amino-5-bromophenyl)propan-2-ol (18 g, 78 mmol) THF (150 mL) solution was added N,N'-carbonyldiimidazole (15.5 g, 94 mmol). The reaction mixture was heated and stirred at 50 °C overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (100 mL). The resulting solution was washed sequentially with 1N HCl (2 × 40 mL), brine (20 mL), dried over anhydrous MgSO4 and filtered. The filtrate was concentrated under reduced pressure to give 6-bromo-4,4-dimethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one (20 g, 100% yield) as a white solid with a melting point of 199-200 °C.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 20, p. 4379 - 4382
[2] Patent: US2002/49204, 2002, A1
[3] Patent: US2002/68735, 2002, A1
[4] Patent: US6436929, 2002, B1
[5] Patent: US6444668, 2002, B1

BROFOXINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BROFOXINE Suppliers

China 56 Europe 1 Germany 2 India 2 United Kingdom 10 United States 13 Global 84

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Shanghai yirong biology science and technology co., ltd

Tel: 18049974220
Fax: +86 (21) 51062076
Email: 3060526242@qq.com
Country: China
ProdList: 995
Advantage: 60

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

More

Less

View Lastest Price from BROFOXINE manufacturers

Honest Joy Holdings Limited

Product: Brofoxine 21440-97-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.3%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one 21440-97-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-03

21440-97-1, BROFOXINERelated Search:

Aniline ALLOSAMIDIN BROFOXINE 2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL

6-BROMO-4,4-DIMETHYL-1,4-DIHYDRO-BENZO[D][1,3]OXAZIN-2-ONE

BROFOXINE

1,2-dihydro-6-bromo-4,4-dimethyl-4h-1-benzoxazin-2-one

4h-4-dimethyl-6-bromo-3,1-benzoxazine-2-one

6-bromo-1,4-dihydro-4,4-dimethyl-2h-1-benzoxazin-2-one

6-bromo-1,4-dihydro-4,4-dimethyl-2h-3,1-benzoxazin-2-one

dimethabrone

6-Bromo-4,4-dimethyl-4H-3,1-benzoxazin-2(1H)-one

F.I.6820

FI-6820

4,4-Dimethyl-6-bromo-1,3-benzoxazine-2-one

6-broMo-4,4-diMethyl-2,4-dihydro-1H-3,1-benzoxazin-2- one

6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one

Brofoxine-4,4-Dimethyl-6-Bromo-1,3-Benxoxazine-2-One(Or)

4,4-Dimethyl-6-bromo-3,1-benzoxazine-2-one (or) 6-Bromo-1,4-dihydro-4,4-dimethyl-2H-3,1-Benzoxazin-2-one (Brofoxine)

2H-3,1-Benzoxazin-2-one, 6-bromo-1,4-dihydro-4,4-dimethyl-

21440-97-1

C10H10BrNO2

Active Pharmaceutical Ingredients