ChemicalBook > CAS DataBase List > BROFOXINE

BROFOXINE

Product Name
BROFOXINE
CAS No.
21440-97-1
Chemical Name
BROFOXINE
Synonyms
FI-6820;F.I.6820;BROFOXINE;dimethabrone;4,4-Dimethyl-6-bromo-1,3-benzoxazine-2-one;4h-4-dimethyl-6-bromo-3,1-benzoxazine-2-one;6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one;6-Bromo-4,4-dimethyl-4H-3,1-benzoxazin-2(1H)-one;6-bromo-1,4-dihydro-4,4-dimethyl-2h-1-benzoxazin-2-one;1,2-dihydro-6-bromo-4,4-dimethyl-4h-1-benzoxazin-2-one
CBNumber
CB1468032
Molecular Formula
C10H10BrNO2
Formula Weight
256.1
MOL File
21440-97-1.mol
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BROFOXINE Property

storage temp. 
2-8°C
CAS DataBase Reference
21440-97-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
W4453
Product name
6-Bromo-4,4-dimethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-one
Packaging
250mg
Price
$126
Updated
2021/12/16
Matrix Scientific
Product number
074123
Product name
6-Bromo-4,4-dimethyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one
Purity
95+%
Packaging
1g
Price
$400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013667
Product name
6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-2H-3,1-BENZOXAZIN-2-ONE
Purity
95.00%
Packaging
1G
Price
$958.65
Updated
2021/12/16
Matrix Scientific
Product number
074123
Product name
6-Bromo-4,4-dimethyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one
Purity
95+%
Packaging
5g
Price
$1069
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013667
Product name
6-BROMO-1,4-DIHYDRO-4,4-DIMETHYL-2H-3,1-BENZOXAZIN-2-ONE
Purity
95.00%
Packaging
5G
Price
$1739.43
Updated
2021/12/16
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BROFOXINE Chemical Properties,Usage,Production

Uses

Antipsychotic.

Synthesis

530-62-1

304853-89-2

21440-97-1

Step 2: Synthesis of 6-bromo-4,4-dimethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; the compound was prepared with reference to U.S. Patent No. 4,522,576 and U.S. Patent No. 6,444,668. to an anhydrous nitrogen-protected 2-(2-amino-5-bromophenyl)propan-2-ol (18 g, 78 mmol) THF (150 mL) solution was added N,N'-carbonyldiimidazole (15.5 g, 94 mmol). The reaction mixture was heated and stirred at 50 °C overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (100 mL). The resulting solution was washed sequentially with 1N HCl (2 × 40 mL), brine (20 mL), dried over anhydrous MgSO4 and filtered. The filtrate was concentrated under reduced pressure to give 6-bromo-4,4-dimethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one (20 g, 100% yield) as a white solid with a melting point of 199-200 °C.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 20, p. 4379 - 4382
[2] Patent: US2002/49204, 2002, A1
[3] Patent: US2002/68735, 2002, A1
[4] Patent: US6436929, 2002, B1
[5] Patent: US6444668, 2002, B1

BROFOXINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BROFOXINE Suppliers

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View Lastest Price from BROFOXINE manufacturers

Honest Joy Holdings Limited
Product
Brofoxine 21440-97-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.3%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one 21440-97-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-02-03

21440-97-1, BROFOXINERelated Search:

Aniline ALLOSAMIDIN BROFOXINE 2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL

  • 6-BROMO-4,4-DIMETHYL-1,4-DIHYDRO-BENZO[D][1,3]OXAZIN-2-ONE
  • BROFOXINE
  • 1,2-dihydro-6-bromo-4,4-dimethyl-4h-1-benzoxazin-2-one
  • 4h-4-dimethyl-6-bromo-3,1-benzoxazine-2-one
  • 6-bromo-1,4-dihydro-4,4-dimethyl-2h-1-benzoxazin-2-one
  • 6-bromo-1,4-dihydro-4,4-dimethyl-2h-3,1-benzoxazin-2-one
  • dimethabrone
  • 6-Bromo-4,4-dimethyl-4H-3,1-benzoxazin-2(1H)-one
  • F.I.6820
  • FI-6820
  • 4,4-Dimethyl-6-bromo-1,3-benzoxazine-2-one
  • 6-broMo-4,4-diMethyl-2,4-dihydro-1H-3,1-benzoxazin-2- one
  • 6-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one
  • Brofoxine-4,4-Dimethyl-6-Bromo-1,3-Benxoxazine-2-One(Or)
  • 4,4-Dimethyl-6-bromo-3,1-benzoxazine-2-one (or) 6-Bromo-1,4-dihydro-4,4-dimethyl-2H-3,1-Benzoxazin-2-one (Brofoxine)
  • 2H-3,1-Benzoxazin-2-one, 6-bromo-1,4-dihydro-4,4-dimethyl-
  • 21440-97-1
  • C10H10BrNO2
  • Active Pharmaceutical Ingredients