3-FLUORO-4-METHYLANISOLE
Application- Product Name
- 3-FLUORO-4-METHYLANISOLE
- CAS No.
- 405-06-1
- Chemical Name
- 3-FLUORO-4-METHYLANISOLE
- Synonyms
- 3-FLUORO-4-METHYLANISOLE;2-Fluoro-4-methoxytoluene;3-Fluoro-4-methylanisole99%;3-Fluoro-4-methylanisole 99%;3-Fluoro-4-Methylbenzyl Ether;2-Fluoro-4-Methoxy-1-Methylbenzene;Benzene, 2-fluoro-4-methoxy-1-methyl-;3-FLUORO-4-METHYLANISOLE ISO 9001：2015 REACH;3-Fluoro-4-Methylanisole[2-Fluoro-4-Methoxytoluene];1-Fluoro-3-methoxy-6-methylbenzene-Fluoro-4-methoxytoluene
- CBNumber
- CB1470721
- Molecular Formula
- C8H9FO
- Formula Weight
- 140.15
- MOL File
- 405-06-1.mol
3-FLUORO-4-METHYLANISOLE Property
- Boiling point:
- 63.5-64°C
- Density
- 1.046±0.06 g/cm3(Predicted)
- refractive index
- 1.4909
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 405-06-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F597018
- Product name
- 3-Fluoro-4-methylanisole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J97693
- Product name
- 3-Fluoro-4-methylanisole
- Packaging
- 5g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 2707-3-X5
- Product name
- 3-Fluoro-4-methylanisole
- Purity
- 99%
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
- Product number
- X4255
- Product name
- 3-Fluoro-4-methylanisole
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- PC8219
- Product name
- 3-Fluoro-4-methylanisole
- Purity
- 99%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
3-FLUORO-4-METHYLANISOLE Chemical Properties,Usage,Production
Application
Studies have reported that 3-fluoro-4-methyl anisole can be used to prepare a diarylphosphine ligand, L10b.
Reactions
3-Fluoro-4-methylanisole is a nucleophilic, ring substituted electron acceptor that can be activated by electron donors. The nitro group and the electron donating substituents on the ring are important for this reactivity. 3-Fluoro-4-methylanisole can form substitution products with methyl or formyl groups in the presence of a strong base such as palladium, 3-fluoro-4-methylphenol, or nitro groups. This reactivity is regiospecific, meaning that the substitution will only occur at one of two possible sites on the ring. 3-Fluoro-4-methylanisole's chemical properties give it both activating and deactivating properties in organic reactions.
Synthesis
50868-72-9
405-06-1
The general procedure for the synthesis of 3-fluoro-4-methylanisole from 5-methoxy-2-methylaniline was as follows: a mixed system of 5-methoxy-2-methylaniline (5.0 g; 36 mmol), concentrated hydrochloric acid (7.6 mL, 12 M solution; 91 mmol), and deionized water (11 mL) was heated and stirred at 60 °C for 15 min until complete dissolution. After the reaction solution was cooled to 0 °C, aqueous sodium nitrite (2.5 g; 36 mmol) was slowly added dropwise to control the internal temperature ≤7 °C. The reaction solution was then stirred at 0 °C for 15 min. The reaction solution was continued to be stirred at 0 °C for 30 min, followed by cautious addition of pre-cooled tetrafluoroboric acid solution (5.3 mL, 48% solution; 40 mmol). The reaction mixture was stirred at 0 °C for 20 min before the resulting brown solid was collected by filtration and washed sequentially with ice water (3 × 10 mL) and deionized water (2 × 10 mL). The solid was dried under high vacuum for 20 h. The solid was then heated with a heat gun until the release of white fumes of boron trifluoride was stopped. The resulting brown oil was extracted with ethyl acetate and water in liquid-liquid extraction, and the organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure, and finally purified by short distillation to obtain the colorless oily product 3-fluoro-4-methylanisole (1.6 g; 31% yield).
References
[1] Patent: US6414002, 2002, B1
3-FLUORO-4-METHYLANISOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-METHYLANISOLE manufacturers
- Product
- 3-FLUORO-4-METHYLANISOLE 405-06-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- 3-Fluoro-4-methylanisole 405-06-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- 2-Fluoro-4-methoxy-1-methylbenzene 405-06-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09