FTO ANTIBODY
Source Reactivity Background References- Product Name
- FTO ANTIBODY
- Chemical Name
- FTO ANTIBODY
- Synonyms
- FTO ANTIBODY
- CBNumber
- CB14723698
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb163266
- Product name
- FTO antibody
- Purity
- Affinity-purified by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $280.5
- Updated
- 2021/12/16
- Product number
- orb101157
- Product name
- FTO antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $402.9
- Updated
- 2021/12/16
- Product number
- orb20045
- Product name
- Fto antibody
- Purity
- Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb37245
- Product name
- FTO antibody
- Purity
- Peptide Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb75186
- Product name
- FTO antibody
- Packaging
- 100μL
- Price
- $584.8
- Updated
- 2021/12/16
FTO ANTIBODY Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
FTO is the first obesity gene product identified by genome-wide association studies and it is associated with the largest effect size for this class of proteins. Multiple single-nucleotide polymorphisms in the first intron of the FTO gene have been associated with increased body weight and obesity. Further studies reported that FTO risk alleles were associated with an increase in energy intake, a reduction of activity, and possibly an increased daily fat intake.FTO is a DNA and RNA demethylase that catalyzes the oxidative demethylation of thymidine and uracil. Among its targets is an mRNA subset involved in regulation of learning, reward behavior, motor functions, and feeding. Loss of the FTO gene in mice leads to postnatal growth retardation and a significant reduction in adipose tissue. Mice deficient in the FTO gene have lean body mass due to increased energy expenditure and systemic activation of sympathetic neurons, while overexpression of FTO in mice leads to increased food intake and results in obesity. These results demonstrate that FTO is functionally involved in energy homeostasis.
References
[1] Frayling, T.M. et al. (2007) Science 316, 889-94.
[2] Scuteri, A. et al. (2007) PLoS Genet 3, e115.
[3] Dina, C. et al. (2007) Nat Genet 39, 724-6.
[4] Gulati, P. and Yeo, G.S. (2013) Diabetologia 56, 2113-21.
[5] Hess, M.E. et al. (2013) Nat Neurosci 16, 1042-8.
[6] Fischer, J. et al. (2009) Nature 458, 894-8.
[7] Tews, D. et al. (2013) Endocrinology 154, 3141-51.
[8] Church, C. et al. (2010) Nat Genet 42, 1086-92.
FTO ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
FTO ANTIBODY Suppliers
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