SK-216

Product Name: SK-216
CAS No.: 654080-03-2
Chemical Name: SK-216
Synonyms: SK-216;SK216,SK 216;SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor;2-[5-[6-(5-tert-butyl-1,3-benzoxazol-2-yl)naphthalen-2-yl]oxypentyl]propanedioate;2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
CBNumber: CB14742819
Molecular Formula: C29H32NNaO6
Formula Weight: 513.57
MOL File: 654080-03-2.mol

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SK-216 Property

Melting point:: >300°C
storage temp.: room temp
solubility: Water (Slightly, Heated)
form: powder
color: white to beige
Water Solubility: Soluble to 5 mM in water with gentle warming

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2248
Product name: SK-216
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $79.82
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2248
Product name: SK-216
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $237.3
Updated: 2025/07/31

Tocris

Product number: 6187
Product name: SK216
Purity: ≥98%(HPLC)
Packaging: 50
Price: $781
Updated: 2021/12/16

Tocris

Product number: 6187
Product name: SK216
Purity: ≥98%(HPLC)
Packaging: 10
Price: $187
Updated: 2021/12/16

TRC

Product number: S550025
Product name: SK-216
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

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SK-216 Chemical Properties,Usage,Production

Uses

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) that limits tumor progression and angiogenesis, a therapeutic target in the management of malignancy.

Biological Activity

SK-216 is an orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1) th at inhibits tumor progression and angiogenesis. SK-216 inhibits migration and tube formation of cultured human umbilical vein endothelial cells induced by various angiogenic factors. SK-116 prevents a formation of gastro-intestinal polyps in Min mice.

in vivo

SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model^[1].

Animal Model:	5-6-week-old male athymic nude mice with 143B-Luc cell^[1]
Dosage:	6.6 μg/200 μL in PBS
Administration:	i.p., once every 3 days
Result:	Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice.

storage

Desiccate at RT

SK-216 Preparation Products And Raw materials

Raw materials

Preparation Products

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SK-216 Suppliers

China 21 Japan 1 United Kingdom 1 United States 4 USA 1 Global 28

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654080-03-2, SK-216Related Search:

SK-216

2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor

SK216,SK 216

2-[5-[6-(5-tert-butyl-1,3-benzoxazol-2-yl)naphthalen-2-yl]oxypentyl]propanedioate

654080-03-2