ChemicalBook > CAS DataBase List > SK-216
SK-216
- Product Name
- SK-216
- CAS No.
- 654080-03-2
- Chemical Name
- SK-216
- Synonyms
- SK-216;SK216,SK 216;SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor;2-[5-[6-(5-tert-butyl-1,3-benzoxazol-2-yl)naphthalen-2-yl]oxypentyl]propanedioate;2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
- CBNumber
- CB14742819
- Molecular Formula
- C29H32NNaO6
- Formula Weight
- 513.57
- MOL File
- 654080-03-2.mol
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SK-216 Property
- Melting point:
- >300°C
- storage temp.
- room temp
- solubility
- Water (Slightly, Heated)
- form
- powder
- color
- white to beige
- Water Solubility
- Soluble to 5 mM in water with gentle warming
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2248
- Product name
- SK-216
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $79.82
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML2248
- Product name
- SK-216
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $237.3
- Updated
- 2025/07/31
Tocris
- Product number
- 6187
- Product name
- SK216
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $781
- Updated
- 2021/12/16
Tocris
- Product number
- 6187
- Product name
- SK216
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $187
- Updated
- 2021/12/16
TRC
- Product number
- S550025
- Product name
- SK-216
- Packaging
- 2.5mg
- Price
- $180
- Updated
- 2021/12/16
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SK-216 Chemical Properties,Usage,Production
Uses
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) that limits tumor progression and angiogenesis, a therapeutic target in the management of malignancy.
Biological Activity
SK-216 is an orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1) th at inhibits tumor progression and angiogenesis. SK-216 inhibits migration and tube formation of cultured human umbilical vein endothelial cells induced by various angiogenic factors. SK-116 prevents a formation of gastro-intestinal polyps in Min mice.
in vivo
SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model[1].
| Animal Model: | 5-6-week-old male athymic nude mice with 143B-Luc cell[1] |
| Dosage: | 6.6 μg/200 μL in PBS |
| Administration: | i.p., once every 3 days |
| Result: | Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice. |
storage
Desiccate at RT
SK-216 Preparation Products And Raw materials
Raw materials
Preparation Products
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