3-Methyl-4-nitrophenol Property

Melting point:

125-130 °C(lit.)

Boiling point:

200℃（decomposition）

Density 

1.2744 (estimate)

refractive index 

1.5744 (estimate)

Flash point:

110℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Sparingly)

form 

powder to crystal

pka

7.39±0.10(Predicted)

color 

Light yellow to Yellow to Orange

Water Solubility 

Soluble in water(1.34g/L).

BRN 

1868105

CAS DataBase Reference

2581-34-2(CAS DataBase Reference)

NIST Chemistry Reference

4-Nitro-5-methylphenol(2581-34-2)

EPA Substance Registry System

4-Nitro-m-cresol (2581-34-2)

Safety

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-36/37-37/39-36-24/25

RIDADR 

UN 2446 6.1/PG 3

WGK Germany 

3

RTECS 

GP2625000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29089000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

3-Methyl-4-nitrophenol Chemical Properties,Usage,Production

Chemical Properties

YELLOWISH TO BEIGE CRYSTALLINE POWDER

Uses

3-Methyl-4-nitrophenol is a biochemical used in the preparation of phosphorothioamidate analogues as antimalarial agents. 3-methyl-4-nitrophenol has anti-androgenic activity. PNMC significantly inhibits basal and hCG-stimulated testosterone production in rats.

Production Methods

m-Cresol is nitrosated in isopropanol solution and the isolated 4-nitroso-m-cresol is treated with aqueous nitric acid to oxidize it to 3-Methyl-4-nitrophenol.

Definition

ChEBI: A C-nitro compound in which the nitro group is attached at C-4 of m-cresol.