ChemicalBook > CAS DataBase List > PSMA-617

PSMA-617

Product Name: PSMA-617
CAS No.: 1702967-37-0
Chemical Name: PSMA-617
Synonyms: PSMA-617;Vipivotide tetraxetan;PSMA617,Vipivotide tetraxetan;Vipivotide tetraxetan (PSMA-617);Vipivotide tetraxetan (PSMA617 TFA);Actinium-225-PSMA-Trillium(BAY3563254);Vipivotide tetraxetan (PSMA-617) ，S8670;N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl];(2S)-2-({[(1S)-1-carboxy-5-[(2S)-3-(naphthalen-2-yl)-2-{[(1s,4s)-4-[(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl]cyclohexyl]formamido}propanamido]pentyl]carbamoyl;L-Lysine, N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]-
CBNumber: CB14796685
Molecular Formula: C49H71N9O16
Formula Weight: 1042.14
MOL File: 1702967-37-0.mol

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PSMA-617 Property

Boiling point:: 1371.9±65.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Water:150.0(Max Conc. mg/mL);100.13(Max Conc. mM)
DMSO:125.0(Max Conc. mg/mL);83.43(Max Conc. mM)
form: Solid
pka: 1.83±0.10(Predicted)
color: White to off-white
InChIKey: JBHPLHATEXGMQR-LFWIOBPJSA-N
SMILES: C(O)(=O)[C@H](CCCCNC(=O)[C@H](CC1=CC=C2C(=C1)C=CC=C2)NC([C@@H]1CC[C@@H](CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)CC1)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P143100
Product name: PSMA-617
Packaging: 1mg
Price: $125
Updated: 2021/12/16

TRC

Product number: P143100
Product name: PSMA-617
Packaging: 2.5mg
Price: $280
Updated: 2021/12/16

TRC

Product number: P143100
Product name: PSMA-617
Packaging: 10mg
Price: $1010
Updated: 2021/12/16

ChemScene

Product number: CS-0065894
Product name: Vipivotidetetraxetan
Purity: 99.38%
Packaging: 10mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0065894
Product name: Vipivotidetetraxetan
Purity: 99.38%
Packaging: 25mg
Price: $2550
Updated: 2021/12/16

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PSMA-617 Chemical Properties,Usage,Production

Uses

PSMA-617 has been used in prostate cancer research, and is a promising prostate-specific membrane antigen-targeted theranostic agent.

in vivo

Organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617) after 1 h (n=3) reveals a high specific uptake in LNCaP tumors and in the kidneys. The high uptake in the kidneys is nearly completely blocked by coinjection of 2 mg of 2-PMPA per kilogram. Other organs such as the liver, lung, and spleen show rather low uptake and no blocking effect, with the exception of the spleen. Tumor-to-background ratios are 7.8 (tumor to blood) and 17.1 (tumor to muscle) at 1 h after injection. As compared with the 68Ga-labeled version, the organ distribution with 177Lu-labeled Vipivotide tetraxetan (PSMA-617) (n=3) show a similar uptake in the LNCaP tumors and in the kidneys. The liver uptake is found to be statistically different. Tumor-to-background ratios determined 1 h after injection show slightly higher values (tumor to blood, 22.1; tumor to muscle, 25.6) than previous organ distribution with 68Ga-labeled Vipivotide tetraxetan (PSMA-617)^[1].

IC 50

Traditional Cytotoxic Agents

PSMA-617 Preparation Products And Raw materials

Raw materials

Preparation Products

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PSMA-617 Suppliers

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View Lastest Price from PSMA-617 manufacturers

Dingwang Technology (Wuhan) Co., Ltd.

Product: PSMA-617 1702967-37-0
Price: US $0.00/GRAM
Min. Order: 1GRAM
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-04

Xian confluore Biological Technology Co., Ltd.

Product: PSMA-617 1702967-37-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: >95.00%
Supply Ability: 10mg
Release date: 2024-04-01

1702967-37-0, PSMA-617Related Search:

Vipivotide tetraxetan Linker

PSMA-617

Vipivotide tetraxetan

L-Lysine, N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]-

Vipivotide tetraxetan (PSMA-617)

PSMA617,Vipivotide tetraxetan

Actinium-225-PSMA-Trillium(BAY3563254)

(((S)-1-Carboxy-5-((S)-3-(naphthalen-2-yl)-2-((1r,4S)-4-((2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl)cyclohexane-1-carboxamido)propanamido)pentyl)carbamoyl)-L-glutamic acid

(2S)-2-({[(1S)-1-carboxy-5-[(2S)-3-(naphthalen-2-yl)-2-{[(1s,4s)-4-[(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)methyl]cyclohexyl]formamido}propanamido]pentyl]carbamoyl

Vipivotide tetraxetan (PSMA617 TFA)

Vipivotide tetraxetan (PSMA-617) ，S8670

N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-N6-[3-(2-naphthalenyl)-N-[[trans-4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]methyl]cyclohexyl]carbonyl]-L-alanyl]

1702967-37-0

C49H71N9O16

ADC