HS1371

Product Name: HS1371
CAS No.: 2158197-70-5
Chemical Name: HS1371
Synonyms: HS1371;CS-2831;HS-1371; HS 1371; HS1371;2158197-70-5;7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline;Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371
CBNumber: CB14800382
Molecular Formula: C24H24N4O
Formula Weight: 384.47
MOL File: 2158197-70-5.mol

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HS1371 Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM)
DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM)
Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM)
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 100mg
Price: $1060.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573183
Product name: HS-1371
Purity: >98%
Packaging: 1g
Price: $3580.2
Updated: 2021/12/16

Ambeed

Product number: A982329
Product name: HS1371
Purity: 97%
Packaging: 5mg
Price: $106
Updated: 2021/12/16

Ambeed

Product number: A982329
Product name: HS1371
Purity: 97%
Packaging: 10mg
Price: $169
Updated: 2021/12/16

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HS1371 Chemical Properties,Usage,Production

Biological Activity

HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro.

in vitro

HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death.

target

Target	Value
RIP3 kinase ()	20.8 nM

HS1371 Preparation Products And Raw materials

Raw materials

Preparation Products

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HS1371 Suppliers

China 48 India 1 United States 7 Global 56

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

2158197-70-5, HS1371Related Search:

HS1371

CS-2831

HS-1371; HS 1371; HS1371;2158197-70-5

Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

HS-1371,Inhibitor,Receptor-interacting protein kinases,RIPK,inhibit,HS 1371,RIP kinase,HS1371

7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline

2158197-70-5

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